Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehensive molecular characterization of 19 Hippo core genes in 9,125 tumor samples across 33 cancer types using multidimensional "omic'' data from The Cancer Genome Atlas. We identify somatic drivers among Hippo genes and the related microRNA (miRNA) regulators, and using functional genomic approaches, we experimentally characterize YAP and TAZ mutation effects and miR-590 and miR-200a regulation for TAZ. Hippo pathway activity is best characterized by a YAP/TAZ transcriptional target signature of 22 genes, which shows robust prognostic power across cancer types. Our elastic-net integrated modeling further reveals cancer-type-specific pathway regul...
The disruption of the Hippo pathway occurs in many cancer types and is associated with cancer progre...
Hippo pathway, originally discovered in Drosophila, is responsible for organ size control. The pathw...
Hippo pathway was initially identified through genetic screens for genes regulating organ size in fr...
Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehens...
Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehens...
Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehens...
Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehens...
Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehens...
Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehens...
Abstract Cancer is a serious health issue in the world due to a large body of cancer-related human d...
Cancer is a serious health issue in the world due to a large body of cancer-related human deaths, an...
Cancer is a serious health issue in the world due to a large body of cancer-related human deaths, an...
The disruption of the Hippo pathway occurs in many cancer types and is associated with cancer progre...
Breast cancer (BC) is the most frequently diagnosed malignancy in women and a major public health co...
Head and neck squamous cell carcinoma (HNSCC) represents a highly prevalent and deadly malignancy wo...
The disruption of the Hippo pathway occurs in many cancer types and is associated with cancer progre...
Hippo pathway, originally discovered in Drosophila, is responsible for organ size control. The pathw...
Hippo pathway was initially identified through genetic screens for genes regulating organ size in fr...
Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehens...
Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehens...
Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehens...
Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehens...
Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehens...
Hippo signaling has been recognized as a key tumor suppressor pathway. Here, we perform a comprehens...
Abstract Cancer is a serious health issue in the world due to a large body of cancer-related human d...
Cancer is a serious health issue in the world due to a large body of cancer-related human deaths, an...
Cancer is a serious health issue in the world due to a large body of cancer-related human deaths, an...
The disruption of the Hippo pathway occurs in many cancer types and is associated with cancer progre...
Breast cancer (BC) is the most frequently diagnosed malignancy in women and a major public health co...
Head and neck squamous cell carcinoma (HNSCC) represents a highly prevalent and deadly malignancy wo...
The disruption of the Hippo pathway occurs in many cancer types and is associated with cancer progre...
Hippo pathway, originally discovered in Drosophila, is responsible for organ size control. The pathw...
Hippo pathway was initially identified through genetic screens for genes regulating organ size in fr...