Add to ORKGIn this work, we have studied the cooling crystallization of the two anhydrous phases of Olanzapine in a stagnant medium in the presence of six solvents with different polarities using a multi-well technology. First, we mesured solubility from 20 °C to 60 °C. The results showed that the solubility increases with the solvent polarity: Methanol > Ethanol >Acetonitril > Ethyl Acetate >Tetrahydrofuran> Toluene. Second, we evidenced the effect of the solvents and the cooling rates on the crystal habit, crystal phase and crystal size distribution
Stress stability testing represents an important part of the drug development process. It is used as...
A random forest model obtained from calculated physicochemical properties of solvents and observed c...
One of the most consequential assumptions of the classical theories of crystal nucleation and growth...
Olanzapine was crystallized from 12 organic solvents alone or in mixture, by cooling in the freezer,...
Anhydrous and hydrated forms of olanzapine were obtained by crystallization using different experime...
An extensive experimental search for solid forms of the antipsychotic compound olanzapine identified...
An extensive experimental search for solid forms of the antipsychotic compound olanzapine identified...
Hydrate formation is a phase transition which can occur during manufacturing processes involving wat...
Communication presented at the 3rd International Congress of CiiEM - Research and Innovation in Huma...
Eleven solid dispersions containing olanzapine, with carriers of different composition (Lutrol® F68,...
In this study, we evaluate the dissolution rate enhancement of solid microcrystalline dispersion (SM...
Solubility and dissolution play a crucial role in the activity and efficacy of an oral drug. Olanzap...
none3noEleven solid dispersions containing olanzapine, with carriers of different composition (Lutro...
The preparation of amorphous and co-amorphous systems (CAMs) effectively addresses the solubility an...
Za djelatnu tvar koja se koristi u liječenju shizofrenije, olanzapin, bilo je potrebno pronaći otapa...
Stress stability testing represents an important part of the drug development process. It is used as...
A random forest model obtained from calculated physicochemical properties of solvents and observed c...
One of the most consequential assumptions of the classical theories of crystal nucleation and growth...
Olanzapine was crystallized from 12 organic solvents alone or in mixture, by cooling in the freezer,...
Anhydrous and hydrated forms of olanzapine were obtained by crystallization using different experime...
An extensive experimental search for solid forms of the antipsychotic compound olanzapine identified...
An extensive experimental search for solid forms of the antipsychotic compound olanzapine identified...
Hydrate formation is a phase transition which can occur during manufacturing processes involving wat...
Communication presented at the 3rd International Congress of CiiEM - Research and Innovation in Huma...
Eleven solid dispersions containing olanzapine, with carriers of different composition (Lutrol® F68,...
In this study, we evaluate the dissolution rate enhancement of solid microcrystalline dispersion (SM...
Solubility and dissolution play a crucial role in the activity and efficacy of an oral drug. Olanzap...
none3noEleven solid dispersions containing olanzapine, with carriers of different composition (Lutro...
The preparation of amorphous and co-amorphous systems (CAMs) effectively addresses the solubility an...
Za djelatnu tvar koja se koristi u liječenju shizofrenije, olanzapin, bilo je potrebno pronaći otapa...
Stress stability testing represents an important part of the drug development process. It is used as...
A random forest model obtained from calculated physicochemical properties of solvents and observed c...
One of the most consequential assumptions of the classical theories of crystal nucleation and growth...