Synthesis of New gamma-Lactams with gem-Difluorinated Side Chains

International audienceA short and efficient approach has been designed for the synthesis of new gamma-lactams that feature gem -difluorinated side-chains in position 4. The key steps involve 1,4-addition of nitroalkane anions on electrophilic gem -difluoroalkenes, followed by a cascade nitro reduction-heterocyclization. This flexible strategy also allows easy introduction of substituents in positions 3 or 5