PENGARUH PEMBERIAN EKSTRAK DAUN UBI JALAR UNGU (IPOMOEA BATATAS) SEBAGAI ANTIINFLAMASI PADA PLANTAR PEDIS TIKUS PUTIH JANTAN (RATTUS NOVERGICUS) YANG DIINDUKSI KARAGENAN

Background: Inflammation is a protective response of organism and tissues from damage. To reduce inflammation, people used NSAID which caused many adverse effect. Purple sweet potato leaves contain chlorogenic acid and quercetin which can inhibit cyclooxygenase-2 and lypoxygenase enzyme also reduce prostaglandin secretion. Objective: To prove the antiinflammatory effect from giving purple sweet potato leaves (Ipomoea batatas) extract to carragenan injected white male rats (Rattus norvegicus. Methods: This experimental study was pre and post-test only control group design for 8 days using 24 male Wistar rats, divided into 4 groups: (1 ) positive control, (2) treatment dose of 300mg/KgBB, (3) treatment dose of 600mg/KgBB, (4) treatment dose of 1200mg/KgBB. Result and Discussion: One Way ANOVA test result show significant effect (p<0,05). Result of Post Hoc test was found significant of differences (p