Pengaruh Alumunium Klorida (AlCl3) Terhada Fungsi Memori Tikus Putih (rattus novergicus strain wistar) Model Hioesterogen

Background : A better technology especially in medical sector make life expectancy increased. It makes neurodegenerative issue increase, for exmpale alzheimer’s disease (AD). Woman have a longer life expectency compare to man, cause woman have a longer life, thus make menapuasal period longer. AD is a degenerative disease that cause decrease in memory function. Until now the etiology is still unclear, but one of studies said that alumunium is a risk factor for AD. Aim: To know the influence of AlCl3 induction towards memory function in rattus novergicus hypoestrogen model Method: Do ovariectomy in rat, then after 4 weeks induce AlCl3To know the influence of AlCl3, the dosage difference (50,100 and 200 mg/Kg orally for 42 days) is used. The perform of rat is checked using morris water maze examination in the day 38-42 of experiment. After the morris water maze examination, calculated the time to reach the hidden platform Result: Result shows that dosage 100mg/Kg of AlCl3 sustain a significant decrease in memory function compare to dosage (50,100,200 mg/Kg) + ovariectomy. This matter probably causes by many factors such as light, the size of maze and atypical alzheimers disease that could happen when the brain is already atrophy but show no symptoms. Conclusions: In this experiment shows that induction of AlCl3100mg/Kg for 6 weeks sustain a significant decrease in memory functio