PCDH10 has been implicated as a tumor suppressor, since epigenetic alterations of this gene have been noted in multiple tumor types. However, to date, studies regarding its role in acute and chronic leukemias are lacking. Here, we have investi- gated the presence of promoter hypermethylation of two CpG islands of the PCDH10 gene by methylation-specific PCR in 215 cases of various subsets of myeloid- and lymphoid-lineage leukemias. We found that PCDH10 promoter hypermethyl- ation was frequent in both B-cell (81.9%) and T-cell (80%) acute lymphoblastic leukemia (ALL), while it was present in low frequency in most subtypes of myeloid leukemias (25.9%) and rare in chronic myeloid leukemia (2.2%). PCDH10 expression was downregulated via promoter...
Cervical cancer (CC) is the second most common cancer in women. Currently, no tractable molecular-ba...
This study examined DNA methylation associated with acute lymphoblastic leukemia (ALL) and showed th...
The past decade has seen an explosion of interest in the epigenetics of cancer, with an increasing u...
PCDH10 is epigenetically inactivated in multiple tumor types; however, studies in mature lymphoid ma...
Abstract Background PCDH10, one of the non-clustered protocadherins, is identified as a tumor suppre...
Epigenetic silencing of tumour suppressor genes (TSG) inactivates TSG functions. Previously, we iden...
Background: Hypermethylation of tumor suppressor gene has been reported in various types of leukemia...
Epigenetic silencing of tumour suppressor genes (TSG) inactivates TSG functions. Previously, we iden...
We used a chromosome 3 wide NotI microarray for identification of epigenetically inactivated genes i...
Promoter hypermethylation mediated gene silencing is a frequent epigenetic finding in many cancers t...
Background and objectives: DNA hypermethylation has been linked to poor treatment outcome in childho...
DNA methylation is tightly regulated during development and is stably maintained in healthy cells. I...
Promoter hypermethylation plays an important role in the inactivation of cancerrelated genes. This...
Global hypomethylation and regional hypermethylation are well-known epigenetic features of cancer, h...
Protocadherins constitute the largest subgroup in the cadherin superfamily of cell adhesion molecule...
Cervical cancer (CC) is the second most common cancer in women. Currently, no tractable molecular-ba...
This study examined DNA methylation associated with acute lymphoblastic leukemia (ALL) and showed th...
The past decade has seen an explosion of interest in the epigenetics of cancer, with an increasing u...
PCDH10 is epigenetically inactivated in multiple tumor types; however, studies in mature lymphoid ma...
Abstract Background PCDH10, one of the non-clustered protocadherins, is identified as a tumor suppre...
Epigenetic silencing of tumour suppressor genes (TSG) inactivates TSG functions. Previously, we iden...
Background: Hypermethylation of tumor suppressor gene has been reported in various types of leukemia...
Epigenetic silencing of tumour suppressor genes (TSG) inactivates TSG functions. Previously, we iden...
We used a chromosome 3 wide NotI microarray for identification of epigenetically inactivated genes i...
Promoter hypermethylation mediated gene silencing is a frequent epigenetic finding in many cancers t...
Background and objectives: DNA hypermethylation has been linked to poor treatment outcome in childho...
DNA methylation is tightly regulated during development and is stably maintained in healthy cells. I...
Promoter hypermethylation plays an important role in the inactivation of cancerrelated genes. This...
Global hypomethylation and regional hypermethylation are well-known epigenetic features of cancer, h...
Protocadherins constitute the largest subgroup in the cadherin superfamily of cell adhesion molecule...
Cervical cancer (CC) is the second most common cancer in women. Currently, no tractable molecular-ba...
This study examined DNA methylation associated with acute lymphoblastic leukemia (ALL) and showed th...
The past decade has seen an explosion of interest in the epigenetics of cancer, with an increasing u...