The effect of N1-dansylspermine, a polyamine analogue and competitive polyamine antagonist, and Ro25,6981, a noncompetitive polyamine antagonist with good affinity and selectivity for the GluN2B subunit, on locomotor activity in naive mice was investigated. Furthermore, the ability of the polyamine antagonists to reverse reserpine-induced hypokinesia was assessed, 24 h after injection of a catecholamine-depleting dose of reserpine (5 mg/kg, subcutaneous), to investigate the therapeutic potential of polyamine antagonists in Parkinson’s disease. N1-dansylspermine significantly decreased locomotor activity in naive animals (P<0.001) but caused a mild, but significant increase in locomotor activity in reserpinized mice at the highest dose teste...
L-DOPA is the mainstay of treatment for Parkinson’s disease (PD). However, over time this drug can p...
Aim: Modulation of electrical activity in the subthalamic nucleus has been therapeutically effective...
Dopamin is one of neurotransmitters of the mammal brain that plays an important role in many functio...
The effect of N1-dansylspermine, a polyamine analogue and competitive polyamine antagonist, and Ro25...
We compared the ability of various dopamine (DA) uptake inhibitors to displace the in vivo striatal ...
The degeneration of the dopaminergic nigrostriatal pathway in Parkinson's disease (PD) is associated...
The antimicrobial agent oxolinic acid, injected i.p. in mice, induced a dose dependent increase in l...
D2 receptors have been studied in relation to therapeutic uses of dopaminergic drugs, and psychomoto...
Guanosine (GUO) is a guanine-based purine nucleoside with important trophic functions and promising ...
<p>DAT-KO mice were placed in the locomotor activity chamber and 30 min later were treated with αMT ...
Dyskinesia (abnormal involuntary movements) is a common complication of l-DOPA pharmacotherapy in Pa...
Thesis (Ph.D. (Pharmaceutical Chemistry))--North-West University, Potchefstroom Campus, 2005.Parkins...
The systemic administration of polyamines (s.c.) produced a dose-dependent motor depression. With hi...
Adenosine A2A antagonists can exert antiparkinsonian effects in animal models. Recent experiments st...
Animal models of motor dysfunction constitute the basis for the screening of new drugs with potentia...
L-DOPA is the mainstay of treatment for Parkinson’s disease (PD). However, over time this drug can p...
Aim: Modulation of electrical activity in the subthalamic nucleus has been therapeutically effective...
Dopamin is one of neurotransmitters of the mammal brain that plays an important role in many functio...
The effect of N1-dansylspermine, a polyamine analogue and competitive polyamine antagonist, and Ro25...
We compared the ability of various dopamine (DA) uptake inhibitors to displace the in vivo striatal ...
The degeneration of the dopaminergic nigrostriatal pathway in Parkinson's disease (PD) is associated...
The antimicrobial agent oxolinic acid, injected i.p. in mice, induced a dose dependent increase in l...
D2 receptors have been studied in relation to therapeutic uses of dopaminergic drugs, and psychomoto...
Guanosine (GUO) is a guanine-based purine nucleoside with important trophic functions and promising ...
<p>DAT-KO mice were placed in the locomotor activity chamber and 30 min later were treated with αMT ...
Dyskinesia (abnormal involuntary movements) is a common complication of l-DOPA pharmacotherapy in Pa...
Thesis (Ph.D. (Pharmaceutical Chemistry))--North-West University, Potchefstroom Campus, 2005.Parkins...
The systemic administration of polyamines (s.c.) produced a dose-dependent motor depression. With hi...
Adenosine A2A antagonists can exert antiparkinsonian effects in animal models. Recent experiments st...
Animal models of motor dysfunction constitute the basis for the screening of new drugs with potentia...
L-DOPA is the mainstay of treatment for Parkinson’s disease (PD). However, over time this drug can p...
Aim: Modulation of electrical activity in the subthalamic nucleus has been therapeutically effective...
Dopamin is one of neurotransmitters of the mammal brain that plays an important role in many functio...