Dynamic contrast-enhanced MR imaging in predicting progression of enhancing lesions persisting after standard treatment in glioblastoma patients: a prospective study

To prospectively explore the value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in predicting the progression of enhancing lesions persisting after standard treatment in patients with surgically resected glioblastoma (GBM). Forty-seven GBM patients, who underwent near-total tumorectomy followed by concurrent chemoradiation therapy (CCRT) with temozolomide (TMZ) between May 2014 and February 2016, were enrolled. Twenty-four patients were finally analyzed for measurable enhancing lesions persisting after standard treatment. DCE-MRI parameters were calculated at enhancing lesions. Mann-Whitney U tests and multivariable stepwise logistic regression were used to compare parameters between progression (n = 16) and non-progression (n = 8) groups. Mean K-trans and v(e) were significantly lower in progression than in non-progression (P = 0.037 and P = 0.037, respectively). The 5th percentile of the cumulative K-trans histogram was also significantly lower in the progression than in non-progression group (P = 0.017). Mean v(e) was the only independent predictor of progression (P = 0.007), with a sensitivity of 100%, specificity of 63%, and an overall accuracy of 88% at a cut-off value of 0.873. DCE-MRI may help predict the progression of enhancing lesions persisting after the completion of standard treatment in patients with surgically resected GBM, with mean v(e) serving as an independent predictor of progression. aEuro cent Enhancing lesions may persist after standard treatment in GBM patients. aEuro cent DCE-MRI may help predict the progression of the enhancing lesions. aEuro cent Mean K (trans) and v (e) were lower in progression than in non-progression group. aEuro cent DCE-MRI may help identify patients requiring close follow-up after standard treatment. aEuro cent DCE-MRI may help plan treatment strategies for GBM patients. (c) European Society of Radiology 20161331sciescopu