Harnessing the IL-7/IL-7R alpha axis to improve tumor immunotherapy
- Johnson, C. Bryce
- Wrangle, John
- Mehrotra, Shikhar
- Li, Zihai
- Paulos, Chrystal M.
- Cole, David J.
- Charles D. Surh
- Rubinstein, Mark P.
Publication date
October 2018
DOI Publisher
Informa UK Limited Journal
OncoImmunologyAbstract
IL-7 and IL-15 are critical for supporting T cells transferred into a lymphopenic environment. As activated CD8(+) T cells downregulate IL-7R alpha, it is thought IL-15 is more important. However, we find that CD8(+) T cells activated with IL-12 have elevated IL-7R alpha and rely on IL-7 for persistence and antitumor immunity. © 2016 Taylor & Francis Group, LLC1221sciescopu
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