In-vitro investigation of susceptibilities to griseofulvin, fluconazole and itraconazole of various dermatophytes [Çeşitli dermatofitlerin griseofulvin, flukonazol ve itrakonazol duyarliliklarinin in-vitro araştirilmasi]

In this study, the in-vitro susceptibilities of dermatophytes isolated from hair, skin and nail specimens collected from patients admitted to our outpatient clinics between 1993-1997 with dermatophytosis lesions, against griseofulvin, fluconazole and itraconazole have been searched. For this purpose, totally 117 dermatophyte strains (61 Trichophyton mentagrophytes, 34 Trichophyton tonsurans, 14 Trichophyton verrucosum, 8 Trichophyton violaceum) isolated from cultures of superficial lesions of the patients were tested for antifungal susceptibility patterns with agar dilution method. The minimal inhibitory concentration (MIC) values of the strains varied in a wide range as 1-25 µg/ml, 1-100 µg/ml and 0.01-10 µg/ml for griseofulvin, fluconazole and itraconazole, respectively. As the standard cut-off values have not been described definitely for dermatophyte sensitivity methods, the results were evaluated as MIC values. The MIC values of the isolates were found to be as follows; in 29 (24.8%) > 10 µg/ml for griseofulvin, in 78 (66.6%) > 10 µg/ml for fluconazole, and in 111 (94.8%) ? 1 µg/ml for itraconazole. It can be concluded that the in-vitro MIC values of dermatophytes were found to be high for griseofulvin and fluconazole