The comparison of rocuronium and vecuronium induced neuromuscular block during sevofluran and isoflurane anaesthesia [Sevofluran ve isofluran anestezisi sirasinda rokuronyum ve vekuronyumun olusturdugu noromuskuler blok'un karsilastirilmasi]

Eighty adult patients were accepted to study undergoing elective orthopedic, laparascopic or plastic surgery following informed consent and approval by our ethical committee. Anaesthesia induction was obtained with thiopentone (5 mg/kg) and maintained with 2 % sevoflurane or 1 % isoflurane + 66 % N2O in oxygen. Peripheric nerve stimulator was set on following anaesthesia induction. The patients were assigned randomly four groups equally. To group I 2 % sevoflurane + vecuronium, to group II 2 % sevoflurane + rocuronium, to group III 1 % isoflurane + vecuronium, to group IV 1 % isoflurane + rocuronium were applied. All patients were intubated when 95 % neuromuscular block obtained. The onset time (T95), clinical duration(T25), recovery index (T75-25) and spontaneous recovery time (T90) and endotracheal intubation conditions were assessed in four groups of patients. Haemodynamic and demographic data did not show any difference among groups (p>0.05). Intubation condition were statistically significant in group I than group II and in group III than group IV (p<0.05). T95 values were found statistically significant long in group I than group II and in group III than group IV (p<0.001). T25 values did not show any difference among groups (p>0.05). T75-25 values were found longer in group I than group II. In conclusion the onset of action of rocuronium was faster than vecuronium whereas vecuronium induced intubation conditions were better than rocuronium. T75-25 and T90 is similar in all groups and 2 % sevoflurane or 1 % isoflurane did not change rocuronium and vecuronium induced neuromuscular block