Objective: In this study, we aimed to contribute prenatal diagnosis in the Çukurova region having high prevalence of hemoglobinopathies by implementing DNA sequencing analysis for the mutations undetectable by conventional methods. Methods: Hematological parameters of two families applied to Cukurova University Prenatal Diagnosis Center were analyzed. Hb variants were screened by cellulose acetate electrophoresis and by HPLC. DNA samples of cases were isolated using automatic DNA extraction machine. Microarray, RFLP, ARMS and Gap-PCR molecular methodologies carried out for determinations of hemoglobin mutations. Unidentified mutations were resolved by means of DNA Sequence Analysis. Results: We identified a previously unreported homozygous ...
WOS: 000308829800011PubMed ID: 23056075Introduction: The frequency of hemoglobinopathies is still hi...
PubMedID: 26984585To contribute to the creation of a mutation map of the region, we aimed to determi...
Objective: The spectrum of α-thalassemias correlates well with the number of affected α-globin genes...
WOS: 000348604900017Objective: In this study, we aimed to contribute prenatal diagnosis in the Cukur...
Amaç: Bu çalışmada hemoglobinopati sıklığının yüksek olduğu Çukurova Bölgesinde geleneksel yöntemler...
WOS: 000356581700007PubMed ID: 25313792Objectives: The Agean is one of the regions in Turkey where t...
PubMed ID: 25313792Objectives: The Agean is one of the regions in Turkey where thalassemias and abno...
Alpha (?) thalassemia is one of the hemoglobinopaties that is inherited by autosomal recessive mode....
TEZ7306Tez (Doktora) -- Çukurova Üniversitesi, Adana, 2009.Kaynakça (s.98-103) var.xii, 109 s. : res...
WOS: 000358146600001PubMed ID: 25939702Molecular test results of 231 individuals referred to our mol...
WOS: A1992HM87600017PubMed ID: 1581238We have analysed the alpha-globin gene defects present in seve...
Objective: Although the calculated carrier frequency for point mutations of the beta-globin gene is ...
This paper reports our experience of molecular analysis and diagnosis of beta-thalassaemia and sickl...
PubMed ID: 25939702Molecular test results of 231 individuals referred to our molecular genetics labo...
Introduction: ß-Thalassemia and hemoglobinopathies are common genetic disorders in Turkey and in thi...
WOS: 000308829800011PubMed ID: 23056075Introduction: The frequency of hemoglobinopathies is still hi...
PubMedID: 26984585To contribute to the creation of a mutation map of the region, we aimed to determi...
Objective: The spectrum of α-thalassemias correlates well with the number of affected α-globin genes...
WOS: 000348604900017Objective: In this study, we aimed to contribute prenatal diagnosis in the Cukur...
Amaç: Bu çalışmada hemoglobinopati sıklığının yüksek olduğu Çukurova Bölgesinde geleneksel yöntemler...
WOS: 000356581700007PubMed ID: 25313792Objectives: The Agean is one of the regions in Turkey where t...
PubMed ID: 25313792Objectives: The Agean is one of the regions in Turkey where thalassemias and abno...
Alpha (?) thalassemia is one of the hemoglobinopaties that is inherited by autosomal recessive mode....
TEZ7306Tez (Doktora) -- Çukurova Üniversitesi, Adana, 2009.Kaynakça (s.98-103) var.xii, 109 s. : res...
WOS: 000358146600001PubMed ID: 25939702Molecular test results of 231 individuals referred to our mol...
WOS: A1992HM87600017PubMed ID: 1581238We have analysed the alpha-globin gene defects present in seve...
Objective: Although the calculated carrier frequency for point mutations of the beta-globin gene is ...
This paper reports our experience of molecular analysis and diagnosis of beta-thalassaemia and sickl...
PubMed ID: 25939702Molecular test results of 231 individuals referred to our molecular genetics labo...
Introduction: ß-Thalassemia and hemoglobinopathies are common genetic disorders in Turkey and in thi...
WOS: 000308829800011PubMed ID: 23056075Introduction: The frequency of hemoglobinopathies is still hi...
PubMedID: 26984585To contribute to the creation of a mutation map of the region, we aimed to determi...
Objective: The spectrum of α-thalassemias correlates well with the number of affected α-globin genes...