Hemoglobin o-padova or ?230(b11)GLU›LYSß2 observed in members of a turkish family

PubMedID: 2869010The testing program of cord blood samples for hemoglobin (Hb) abnormalities, presently conducted in a few centers of Turkish Universities, sometimes detects rare variants which may or may not affect the health of the newborn. One example to be described here is O-Padova which has been observed once before (1). The variant was detected in the blood of a newborn girl by starch gel electrophoresis at pH 9.0 (2); the mobility of the variant (presumably ?2X?) was slightly slower than that of Hb C (or ?2ß26 Glu›Lys) (Fig. 1). Red cell lysates from the father and a 2-year-old brother contained a different Hb component with a mobility distinctly faster than that of Hb A2 or of Hb C; a minute quantity of a similar component (presumably ?2 X 2) was also present in the cord blood red cell lysate of Baby E (Fig. 1). The baby was retested when 40 days old; her hematological values and those of her father and brother were normal (Table I). Quantitation by cation exchange high performance liquid chromatography (HPLC) (3) gave total Hb X values of 15.4% for the baby (Hb X + Hb Fx), 18.3% for the father (Hb X + Hb X2), and 12.8% for the brother (Hb X + Hb X2) (see also Table I). © 1985 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.HLB-05168, HLB-15158Diagnosis Unit of the Turkish Scientific and Technical Research Foundation, and by USPHS Research Grants HLB-05168 and HLB-15158. This is contribution 110927 of the Department of Cell and Molecular Biology at the Medical College of Georgia in Augusta, Georgia