Chromosomal aberrations in cultured human lymphocytes treated with the mixtures of carbosulfan, ethyl carbamate and ethyl methanesulfonate

The aim of this study was to investigate the ability of the mixtures of carbosulfan (C) (the effective ingredient of 'marshal', an insecticide/nematocide) and ethyl carbamate (EC) (carcinogen) and also the mixtures of carbosulfan and ethyl methanesulfonate (EMS) (mutagen) to induce the chromosomal aberrations (CA) in human peripheral lymphocytes and to investigate whether the test substances as a mixture had any synergistic effect. All the mixtures of the test substances increased the formation of chromosomal aberrations at all the concentrations and treatment times compared to the control groups. The combination of carbosulfan and EC synergistically increased the formation of CA, at the same concentrations of both carbosulfan and EC at 48 h treatment time. The combination of carbosulfan and EMS also synergistically increased the formation of CA especially at the high concentrations for 48 h treatment times