WOS: 000444369100002PubMed: 30160153BACKGROUND: One of the important risk factors for dementia is chronic cerebral hypoperfusion (CCH) especially in patients with cerebrovascular disease. OBJECTIVES: In the present study, using rat model of bilateral common carotid artery occlusion, the possible protective effects of ethyl pyruvate (EP) have been explored in terms of memory impairment, oxidative stress, and levels of caspase-3, Na-K ATPase, and IL-1 beta. METHODS: Rats were treated with EP (50 mg/kg, i.p) for 4 weeks. Cognitive function was evaluated by Morris Water Maze (MWM). Both levels of caspase-3 and Na-K ATPase in tissue, IL-1 beta in plasma were measured by ELISA method. Status of oxidative stress in brain was assessed by the measur...
Background: Ethyl pyruvate (EP) has been reported to offer a protective effect against ischemic inju...
Background—Neonatal hypoxia-ischemia (HI) remains a major cause of severe brain damage and is often ...
3′-Daidzein sulfonate sodium (DSS) is a new synthetic water-soluble compound derived from daidzein, ...
BACKGROUND: One of the important risk factors for dementia is chronic cerebral hypoperfusion (CCH) e...
Background and Purpose—Pyruvate is known to be cytoprotective through antioxidant and anti-inflammat...
Background and Purpose—Pyruvate is known to be cytoprotective through antioxidant and anti-inflammat...
Background Chronic cerebral hypoperfusion has been linked with cognitive decline in aging and Alzhe...
A persistent reduction in regional cerebral blood flow (CBF) compromises memory and cognitive functi...
Background: A persistent reduction in regional cerebral blood flow (CBF) compromises memory and cogn...
Transient cerebral ischemia (TCI) occurs when blood flow to the brain is ceased or dramatically redu...
Background Chronic cerebral hypoperfusion has been linked with cognitive decline in aging and Alzh...
Emerging evidence indicates the pronounced role of inflammasome activation linked to reactive oxygen...
Vascular dementia (VaD) is a progressive cognitive impairment caused by a reduced blood supply to th...
Background/Aims: An enriched environment (EE) ameliorates learning and memory impairments induced by...
The fixed oil of black cumin seeds, Nigella sativa L. (NSO), has shown considerable antioxidant and ...
Background: Ethyl pyruvate (EP) has been reported to offer a protective effect against ischemic inju...
Background—Neonatal hypoxia-ischemia (HI) remains a major cause of severe brain damage and is often ...
3′-Daidzein sulfonate sodium (DSS) is a new synthetic water-soluble compound derived from daidzein, ...
BACKGROUND: One of the important risk factors for dementia is chronic cerebral hypoperfusion (CCH) e...
Background and Purpose—Pyruvate is known to be cytoprotective through antioxidant and anti-inflammat...
Background and Purpose—Pyruvate is known to be cytoprotective through antioxidant and anti-inflammat...
Background Chronic cerebral hypoperfusion has been linked with cognitive decline in aging and Alzhe...
A persistent reduction in regional cerebral blood flow (CBF) compromises memory and cognitive functi...
Background: A persistent reduction in regional cerebral blood flow (CBF) compromises memory and cogn...
Transient cerebral ischemia (TCI) occurs when blood flow to the brain is ceased or dramatically redu...
Background Chronic cerebral hypoperfusion has been linked with cognitive decline in aging and Alzh...
Emerging evidence indicates the pronounced role of inflammasome activation linked to reactive oxygen...
Vascular dementia (VaD) is a progressive cognitive impairment caused by a reduced blood supply to th...
Background/Aims: An enriched environment (EE) ameliorates learning and memory impairments induced by...
The fixed oil of black cumin seeds, Nigella sativa L. (NSO), has shown considerable antioxidant and ...
Background: Ethyl pyruvate (EP) has been reported to offer a protective effect against ischemic inju...
Background—Neonatal hypoxia-ischemia (HI) remains a major cause of severe brain damage and is often ...
3′-Daidzein sulfonate sodium (DSS) is a new synthetic water-soluble compound derived from daidzein, ...