Unpredicted effects of ankaferd® on cartilage tissue

Objective: This study aims to investigate the histopathological changes secondary to the administration of Ankaferd Blood Stopper ® (ABS) into the auricular cartilage. Materials and methods: Both of the auricular cartilages of thirty New Zealand rabbits were marked with tattoo ink. A 0.2-cc ABS (study group, n: 30) and 0.2 cc physiological saline (control group, n: 30) were subcutaneously infused into the right auricle and left auricle, respectively. All layers were removed at 14 days. Results: The ABS group had significantly higher level of fibrosis, necrosis, foreign body reaction, inflammation, and cartilage degeneration, compared to the controls. Conclusion: Our study results showed that ABS administration into a closed cavity led to a significantly increased fibrosis and necrosis in the auricular cartilage. © 2015, E-Century Publishing Corporation. All rights reserved