Ultra-small superparamagnetic iron oxide enhancement is associated with higher loss of brain tissue structure in clinically isolated syndrome
- Maarouf, Adil
- Ferré, Jean-Christophe
- Zaaraoui, W
- Le Troter, Arnaud
- Bannier, Elise
- Berry, Isabelle
- Guye, Maxime
- Pierot, Laurent
- Barillot, Christian
- Pelletier, Jean
- Tourbah, Ayman
- Edan, Gilles
- Audoin, Bertrand
- Ranjeva, Jean-Philippe
DOIAbstract
International audienceMacrophages are important components of inflammatory processes in multiple sclerosis, closely linked to axonal loss, and can now be observed in vivo using ultra-small superparamagnetic iron oxide (USPIO). In the present 1-year longitudinal study, we aimed to determine the prevalence and the impact on tissue injury of macrophage infiltration in patients after the first clinical event of multiple sclerosis
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