OBJECTIVE: Endothelial cells exposed to laminar shear stress express a thick glycocalyx on their surface that plays an important role in reducing vascular permeability and endothelial anti-inflammatory, antithrombotic, and antiangiogenic properties. Production and maintenance of this glycocalyx layer is dependent on cellular carbohydrate synthesis, but its regulation is still unknown. Approach and Results: Here, we show that biosynthesis of the major structural component of the endothelial glycocalyx, hyaluronan, is regulated by shear. Both in vitro as well as in in vivo, hyaluronan expression on the endothelial surface is increased on laminar shear and reduced when exposed to oscillatory flow, which is regulated by KLF2 (Krüppel-like Facto...
BACKGROUND: The endothelial glycocalyx plays a pivotal role in regulating blood flow, filtering bloo...
The endothelial glycocalyx exerts a wide array of vasculoprotective effects via inhibition of coagul...
Leukocyte adhesion to the endothelium is an early step in the pathogenesis of atherosclerosis. Effec...
Objective: Endothelial cells exposed to laminar shear stress express a thick glycocalyx on their sur...
Objective: Cellular metabolism was recently shown to regulate endothelial cell phenotype profoundly....
The endothelial glycocalyx (EG) is critically involved in vascular integrity and homeostasis, where ...
The endothelial glycocalyx is critically involved in vascular integrity and homeostasis, by regulati...
The endothelial glycocalyx is essential for adult vascular homeostasis but its formation during vasc...
Flow hemodynamics regulates endothelial cell (EC) responses and laminar shear stress induces an athe...
All human cells are coated by a surface layer of proteoglycans, glycosaminoglycans (GAGs) and plasma...
All human cells are coated by a surface layer of proteoglycans, glycosaminoglycans (GAGs) and plasma...
The endothelial glycocalyx is vital for mechanotransduction and endothelial barrier integrity. We pr...
Endothelial cells (ECs) are subjected to physical forces such as shear stress (SS) induced by blood ...
BACKGROUND: A glycocalyx envelope consisting of proteoglycans and adhering proteins covers endotheli...
Rationale: The endothelial cell glycocalyx (GCX) is a mechanosensor that plays a key role in protect...
BACKGROUND: The endothelial glycocalyx plays a pivotal role in regulating blood flow, filtering bloo...
The endothelial glycocalyx exerts a wide array of vasculoprotective effects via inhibition of coagul...
Leukocyte adhesion to the endothelium is an early step in the pathogenesis of atherosclerosis. Effec...
Objective: Endothelial cells exposed to laminar shear stress express a thick glycocalyx on their sur...
Objective: Cellular metabolism was recently shown to regulate endothelial cell phenotype profoundly....
The endothelial glycocalyx (EG) is critically involved in vascular integrity and homeostasis, where ...
The endothelial glycocalyx is critically involved in vascular integrity and homeostasis, by regulati...
The endothelial glycocalyx is essential for adult vascular homeostasis but its formation during vasc...
Flow hemodynamics regulates endothelial cell (EC) responses and laminar shear stress induces an athe...
All human cells are coated by a surface layer of proteoglycans, glycosaminoglycans (GAGs) and plasma...
All human cells are coated by a surface layer of proteoglycans, glycosaminoglycans (GAGs) and plasma...
The endothelial glycocalyx is vital for mechanotransduction and endothelial barrier integrity. We pr...
Endothelial cells (ECs) are subjected to physical forces such as shear stress (SS) induced by blood ...
BACKGROUND: A glycocalyx envelope consisting of proteoglycans and adhering proteins covers endotheli...
Rationale: The endothelial cell glycocalyx (GCX) is a mechanosensor that plays a key role in protect...
BACKGROUND: The endothelial glycocalyx plays a pivotal role in regulating blood flow, filtering bloo...
The endothelial glycocalyx exerts a wide array of vasculoprotective effects via inhibition of coagul...
Leukocyte adhesion to the endothelium is an early step in the pathogenesis of atherosclerosis. Effec...