OBJECTIVE To evaluate the effect of a romifidine infusion on antinociception and sedation, and to investigate its relationship with plasma concentration. STUDY DESIGN Prospective, experimental, nonrandomized trial. ANIMALS A total of 10 healthy adult warmblood horses. METHODS Romifidine (loading dose: 0.08 mg kg-1, infusion: 0.03 mg kg-1 hour-1) was administered intravenously over 120 minutes. Romifidine plasma concentrations were determined by capillary electrophoresis. Sedation quality and nociceptive thresholds were evaluated at regular time points before, during and after romifidine administration. The nociceptive withdrawal reflex was elicited by electrical stimulation at the thoracic limb using a dedicated thresho...
Abstract Background Romifidine, an α-2 adrenoceptor agonist, is a widely-used sedative in equine med...
NTRODUCTION Flupirtine (FLU) is a non-opioid analgesic drug with no antipyretic or antiphlogistic ...
DESIGN Original study. OBJECTIVE To evaluate the effect of sedation with romifidine hydroch...
OBJECTIVE To evaluate the antinociceptive effect of a bolus of intravenous levomethadone administ...
Objectives: To investigate the effects of MK‐467 on sedation quality, and cardiopulmonary and pharma...
The aims of this study were to assess the plasma concentrations of romifidine in horses after intrav...
none6The aim of this study was to define the levels of romifidine in plasma and red blood cells (RB...
Objective: To compare xylazine and romifidine constant rate infusion (CRI) protocols regarding degre...
OBJECTIVE: To evaluate and compare the antinociceptive effects of the three alpha-2 agonists, detomi...
Objective: To evaluate the effects of a constant rate infusion (CRI) of romifidine on the requiremen...
Compararam-se os efeitos sedativos e antinociceptivos da romifidina (0,1mg/kg) e da xilazina (1,0mg/...
Dexmedetomidine and lignocaine IV are used clinically to provide analgesia in horses. The aims of th...
The aim of the study was to describe the pharmacokinetics and selected pharmacodynamics of intraveno...
Background: Romifidine, an alpha-2 adrenoceptor agonist, is a widely-used sedative in equine medicin...
Clinical and behavioral effects of intravenous injection of romifidine (60mcg/kg) or amitraz (0.4mg/...
Abstract Background Romifidine, an α-2 adrenoceptor agonist, is a widely-used sedative in equine med...
NTRODUCTION Flupirtine (FLU) is a non-opioid analgesic drug with no antipyretic or antiphlogistic ...
DESIGN Original study. OBJECTIVE To evaluate the effect of sedation with romifidine hydroch...
OBJECTIVE To evaluate the antinociceptive effect of a bolus of intravenous levomethadone administ...
Objectives: To investigate the effects of MK‐467 on sedation quality, and cardiopulmonary and pharma...
The aims of this study were to assess the plasma concentrations of romifidine in horses after intrav...
none6The aim of this study was to define the levels of romifidine in plasma and red blood cells (RB...
Objective: To compare xylazine and romifidine constant rate infusion (CRI) protocols regarding degre...
OBJECTIVE: To evaluate and compare the antinociceptive effects of the three alpha-2 agonists, detomi...
Objective: To evaluate the effects of a constant rate infusion (CRI) of romifidine on the requiremen...
Compararam-se os efeitos sedativos e antinociceptivos da romifidina (0,1mg/kg) e da xilazina (1,0mg/...
Dexmedetomidine and lignocaine IV are used clinically to provide analgesia in horses. The aims of th...
The aim of the study was to describe the pharmacokinetics and selected pharmacodynamics of intraveno...
Background: Romifidine, an alpha-2 adrenoceptor agonist, is a widely-used sedative in equine medicin...
Clinical and behavioral effects of intravenous injection of romifidine (60mcg/kg) or amitraz (0.4mg/...
Abstract Background Romifidine, an α-2 adrenoceptor agonist, is a widely-used sedative in equine med...
NTRODUCTION Flupirtine (FLU) is a non-opioid analgesic drug with no antipyretic or antiphlogistic ...
DESIGN Original study. OBJECTIVE To evaluate the effect of sedation with romifidine hydroch...