Nitroxide functionalised antibiotics for the eradication of bacterial biofilms

Bacterial biofilms are a leading cause of life-threatening and device-related infections worldwide. Biofilm related infections are notoriously difficult to treat as they are highly tolerant to conventional antibiotics. This project has designed and synthesised a new class of antibiotics to circumvent biofilm tolerance and shown that the prepared compounds could eradicate several medically important pathogens (P. aeruginosa, E. coli, and S. aureus). Importantly, as these compounds are hybrids of drugs that are already used clinically as stand-alone therapies, they demonstrate great potential to be translated into therapies in the near future