Algorithm and Hardware Design for High Volume Rate 3-D Medical Ultrasound Imaging

abstract: Ultrasound B-mode imaging is an increasingly significant medical imaging modality for clinical applications. Compared to other imaging modalities like computed tomography (CT) or magnetic resonance imaging (MRI), ultrasound imaging has the advantage of being safe, inexpensive, and portable. While two dimensional (2-D) ultrasound imaging is very popular, three dimensional (3-D) ultrasound imaging provides distinct advantages over its 2-D counterpart by providing volumetric imaging, which leads to more accurate analysis of tumor and cysts. However, the amount of received data at the front-end of 3-D system is extremely large, making it impractical for power-constrained portable systems. In this thesis, algorithm and hardware design techniques to support a hand-held 3-D ultrasound imaging system are proposed. Synthetic aperture sequential beamforming (SASB) is chosen since its computations can be split into two stages, where the output generated of Stage 1 is significantly smaller in size compared to the input. This characteristic enables Stage 1 to be done in the front end while Stage 2 can be sent out to be processed elsewhere. The contributions of this thesis are as follows. First, 2-D SASB is extended to 3-D. Techniques to increase the volume rate of 3-D SASB through a new multi-line firing scheme and use of linear chirp as the excitation waveform, are presented. A new sparse array design that not only reduces the number of active transducers but also avoids the imaging degradation caused by grating lobes, is proposed. A combination of these techniques increases the volume rate of 3-D SASB by 4\texttimes{} without introducing extra computations at the front end. Next, algorithmic techniques to further reduce the Stage 1 computations in the front end are presented. These include reducing the number of distinct apodization coefficients and operating with narrow-bit-width fixed-point data. A 3-D die stacked architecture is designed for the front end. This highly parallel architecture enables the signals received by 961 active transducers to be digitalized, routed by a network-on-chip, and processed in parallel. The processed data are accumulated through a bus-based structure. This architecture is synthesized using TSMC 28 nm technology node and the estimated power consumption of the front end is less than 2 W. Finally, the Stage 2 computations are mapped onto a reconfigurable multi-core architecture, TRANSFORMER, which supports different types of on-chip memory banks and run-time reconfigurable connections between general processing elements and memory banks. The matched filtering step and the beamforming step in Stage 2 are mapped onto TRANSFORMER with different memory configurations. Gem5 simulations show that the private cache mode generates shorter execution time and higher computation efficiency compared to other cache modes. The overall execution time for Stage 2 is 14.73 ms. The average power consumption and the average Giga-operations-per-second/Watt in 14 nm technology node are 0.14 W and 103.84, respectively.Dissertation/ThesisDoctoral Dissertation Engineering 201