Age of onset determines intrinsic functional brain architecture in Friedreich ataxia.

Naeije, Gilles
Wens, Vincent
Coquelet, Nicolas
Sjogärd, Martin
Goldman, Serge
Pandolfo, Massimo
De Tiege, Xavier

Open link

Publication date

January 2020

DOI

10.1002/acn3.50966

Publisher

Wiley

Abstract

Friedreich ataxia (FRDA) is the commonest hereditary ataxia in Caucasians. Most patients are homozygous for expanded GAA triplet repeats in the first intron of the frataxin (FXN) gene, involved in mitochondrial iron metabolism. Here, we used magnetoencephalography (MEG) to characterize the main determinants of FRDA-related changes in intrinsic functional brain architecture.info:eu-repo/semantics/publishe