In this master thesis I consider primarily the NK model for fitness landscapes and adaptive walks on such landscapes. Specifically a notation for a low-dimensional representation of (reciprocal) sign epistasis on the space of genetic loci is introduced for these models and used to derive sign-dependent properties, in particular the so called accessibility property of the landscape
Fitness landscapes are a powerful metaphor for understanding the evolution of biological systems. Th...
The relationship between the shape of a fitness landscape and the underlying gene interactions, or e...
Stochastic noise in gene expression causes variation in the development of phenotypes, making such n...
Kauffman’s seminal NK model was introduced to relate the properties of fitness landscapes to the ext...
NK fitness landscapes are stochastically generated fitness functions on bit strings, parameterized (...
Evolution is an incredibly complex process that has been the subject of scientific study for well ov...
<p>a) Illustrating reciprocal sign epistasis. When there is no epistasis the combined effects of two...
This thesis will be about trying to find out which paths evolution took for some selected small org...
Along with being consequential for evolution, epistasis is also quite prevalent in nature. Thus, it ...
Epistatic interactions between mutations add substantial complexity to adaptive landscapes, and are ...
Empirical essays of fitness landscapes suggest that they may be rugged, that is having multiple fitn...
61 pages, 9 figuresInternational audienceKauffman's NK-model is a paradigmatic example of a class of...
Background: Understanding interactions between mutations and how they affect fitness is a central pr...
The mapping from genotype to phenotype to fitness typically involves multiple nonlinearities that ca...
[EN] Epistasis refers to the nonadditive interactions between genes in determining phenotypes. Consi...
Fitness landscapes are a powerful metaphor for understanding the evolution of biological systems. Th...
The relationship between the shape of a fitness landscape and the underlying gene interactions, or e...
Stochastic noise in gene expression causes variation in the development of phenotypes, making such n...
Kauffman’s seminal NK model was introduced to relate the properties of fitness landscapes to the ext...
NK fitness landscapes are stochastically generated fitness functions on bit strings, parameterized (...
Evolution is an incredibly complex process that has been the subject of scientific study for well ov...
<p>a) Illustrating reciprocal sign epistasis. When there is no epistasis the combined effects of two...
This thesis will be about trying to find out which paths evolution took for some selected small org...
Along with being consequential for evolution, epistasis is also quite prevalent in nature. Thus, it ...
Epistatic interactions between mutations add substantial complexity to adaptive landscapes, and are ...
Empirical essays of fitness landscapes suggest that they may be rugged, that is having multiple fitn...
61 pages, 9 figuresInternational audienceKauffman's NK-model is a paradigmatic example of a class of...
Background: Understanding interactions between mutations and how they affect fitness is a central pr...
The mapping from genotype to phenotype to fitness typically involves multiple nonlinearities that ca...
[EN] Epistasis refers to the nonadditive interactions between genes in determining phenotypes. Consi...
Fitness landscapes are a powerful metaphor for understanding the evolution of biological systems. Th...
The relationship between the shape of a fitness landscape and the underlying gene interactions, or e...
Stochastic noise in gene expression causes variation in the development of phenotypes, making such n...