Pancreatic-type ribonucleases (ptRNases) are prevalent secretory enzymes that catalyze the cleavage of RNA. Ribonuclease inhibitor (RI) is a cytosolic protein that has femtomolar affinity for ptRNases, affording protection from the toxic catalytic activity of ptRNases, which can invade human cells. A human ptRNase variant that is resistant to inhibition by RI is a cytotoxin that is undergoing a clinical trial as a cancer chemotherapeutic agent. We find that the ptRNase and protein kinases in the ERK pathway exhibit strongly synergistic toxicity toward lung cancer cells (including a KRAS[superscript G12C] variant) and melanoma cells (including BRAF[superscript V600E] variants). The synergism arises from inhibiting the phosphorylation of RI a...
Molecular properties and possible mechanisms of action of cytotoxic ribonucleases (RNases), potentia...
Despite the significant advances in cancer research made in recent years, this disease remains one o...
© 2020 National Research University Higher School of Economics One of the approaches used to elimina...
Ribonucleases represent a new class of antitumor RNA-damaging drugs. However, many wild-type members...
Ribonucleases are promising agents for use in anticancer therapy. Engineering a nuclear localization...
Onconaseâ (ONC) is a homolog of RNase A that is in clinical trials as a cancer chemotherapeutic agen...
ABSTRACT: The ribonuclease inhibitor (RI) is a cytosolic protein and a potent inhibitor of bovine pa...
Many ribonucleases (RNases) are highly cytotoxic. In some cases, they attack selectively malignant c...
Several ribonucleases (RNases) are known to exert a toxic effect on tumor cells, but the mechanism o...
Mammalian ribonucleases interact very strongly with the intracellular ribonuclease inhibitor (RI). E...
AbstractMany ribonucleases (RNases) are highly cytotoxic. In some cases, they attack selectively mal...
AbstractHuman pancreatic ribonuclease (RNase 1) is a small secretory protein that catalyzes the clea...
The characteristics and the possible mechanisms of action of cytotoxic ribonucleases (RNases), promi...
Background: Ribonucleases are promising agents for use in anticancer therapy. Among the different ri...
<div><p>Novel data showing an important role of microRNAs in mediating tumour progression opened a n...
Molecular properties and possible mechanisms of action of cytotoxic ribonucleases (RNases), potentia...
Despite the significant advances in cancer research made in recent years, this disease remains one o...
© 2020 National Research University Higher School of Economics One of the approaches used to elimina...
Ribonucleases represent a new class of antitumor RNA-damaging drugs. However, many wild-type members...
Ribonucleases are promising agents for use in anticancer therapy. Engineering a nuclear localization...
Onconaseâ (ONC) is a homolog of RNase A that is in clinical trials as a cancer chemotherapeutic agen...
ABSTRACT: The ribonuclease inhibitor (RI) is a cytosolic protein and a potent inhibitor of bovine pa...
Many ribonucleases (RNases) are highly cytotoxic. In some cases, they attack selectively malignant c...
Several ribonucleases (RNases) are known to exert a toxic effect on tumor cells, but the mechanism o...
Mammalian ribonucleases interact very strongly with the intracellular ribonuclease inhibitor (RI). E...
AbstractMany ribonucleases (RNases) are highly cytotoxic. In some cases, they attack selectively mal...
AbstractHuman pancreatic ribonuclease (RNase 1) is a small secretory protein that catalyzes the clea...
The characteristics and the possible mechanisms of action of cytotoxic ribonucleases (RNases), promi...
Background: Ribonucleases are promising agents for use in anticancer therapy. Among the different ri...
<div><p>Novel data showing an important role of microRNAs in mediating tumour progression opened a n...
Molecular properties and possible mechanisms of action of cytotoxic ribonucleases (RNases), potentia...
Despite the significant advances in cancer research made in recent years, this disease remains one o...
© 2020 National Research University Higher School of Economics One of the approaches used to elimina...