Regioselective 2′‐Silylation of Purine Ribonucleosides for Phosphoramidite RNA Synthesis

This unit describes high‐yield procedures for protection of purine ribonucleosides based on a reaction that allows concomitant highly regioselective 2′‐silylation and 3′‐phosphitylation to give, in one step, monomers that are ready for H‐phosphonate synthesis. For preparation of phosphoramidites, the H‐phosphonate monoester is cleaved without silyl migration to give intermediates ready for phosphitylation by standard methods.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153167/1/cpnc0208.pd