Vascular dysfunction is an important phenomenon in hypertension. We hypothesized that angiotensin II (AngII) affects transcriptome in the vasculature in a region-specific manner, which may help to identify genes related to vascular dysfunction in AngII-induced hypertension. Mesenteric artery and aortic transcriptome was profiled using Illumina WG-6v2.0 chip in control and AngII infused (490 ng/kg/min) hypertensive mice. Gene set enrichment and leading edge analyses identified Sphingosine kinase 1 (Sphk1) in the highest number of pathways affected by AngII. Sphk1 mRNA, protein and activity were up-regulated in the hypertensive vasculature. Chronic sphingosine-1-phosphate (S1P) infusion resulted in a development of significantly increased vas...
Hypertension is, amongst others, characterized by endothelial dysfunction and vascular remodeling. A...
We recently demonstrated that selective expression of the Rho GTPase-activating protein ARHGAP42 in ...
Several vasoregulatory systems including the renin-angiotensin system, sympathetic vasoregulation, a...
Background/Aims: Angiotensin II (Ang II)-mediated hypertension is a major risk factor for cardiovasc...
Background Hypertension is, amongst others, characterized by endothelial dysfunction and vascular re...
A major hemodynamic abnormality in hypertension is increased peripheral resistance due to changes in...
BACKGROUND: Hypertension is a complex disease with many contributory genetic and environmental fact...
It is known that hypertension is associated with endothelial dysfunction and that Angiotensin II (An...
This article is made available for unrestricted research re-use and secondary analysis in any form o...
Although hypertension is a worldwide health issue, an incomplete understanding of its etiology has h...
Resistance arteries undergo structural changes (vascular remodelling) in hypertension. These changes...
The renin angiotensin system (RAS) exerts many diverse physiological functions throughout the body, ...
Autophagy is an intracellular degradation system that disassembles cytoplasmic components through au...
Hypertension is, amongst others, characterized by endothelial dysfunction and vascular remodeling. A...
Objective— Human endothelial cells use the multidrug resistance protein-1 (MRP1) to export glutathio...
Hypertension is, amongst others, characterized by endothelial dysfunction and vascular remodeling. A...
We recently demonstrated that selective expression of the Rho GTPase-activating protein ARHGAP42 in ...
Several vasoregulatory systems including the renin-angiotensin system, sympathetic vasoregulation, a...
Background/Aims: Angiotensin II (Ang II)-mediated hypertension is a major risk factor for cardiovasc...
Background Hypertension is, amongst others, characterized by endothelial dysfunction and vascular re...
A major hemodynamic abnormality in hypertension is increased peripheral resistance due to changes in...
BACKGROUND: Hypertension is a complex disease with many contributory genetic and environmental fact...
It is known that hypertension is associated with endothelial dysfunction and that Angiotensin II (An...
This article is made available for unrestricted research re-use and secondary analysis in any form o...
Although hypertension is a worldwide health issue, an incomplete understanding of its etiology has h...
Resistance arteries undergo structural changes (vascular remodelling) in hypertension. These changes...
The renin angiotensin system (RAS) exerts many diverse physiological functions throughout the body, ...
Autophagy is an intracellular degradation system that disassembles cytoplasmic components through au...
Hypertension is, amongst others, characterized by endothelial dysfunction and vascular remodeling. A...
Objective— Human endothelial cells use the multidrug resistance protein-1 (MRP1) to export glutathio...
Hypertension is, amongst others, characterized by endothelial dysfunction and vascular remodeling. A...
We recently demonstrated that selective expression of the Rho GTPase-activating protein ARHGAP42 in ...
Several vasoregulatory systems including the renin-angiotensin system, sympathetic vasoregulation, a...