Within the corneal limbal epithelium there exist limbal stem cells (LSC) which under suitable conditions can regenerate their population or differentiate into corneal epithelial cells. However, upon limbal damage, the cells differentiate irreversibly and do not self-renew. One of the causes of the damage of progenitor cells and their niche is a long-term use of eye drops containing preservatives. While the side effects are related to the antimicrobial activity of such eye drops, damage to cellular and cytoplasmic membranes as well as enzymatic reactions can concurrently cause disorders of normal ocular surface tissue. The aim of this study was to evaluate the toxic effects of the preservative used in eye drops – benzalkonium chloride (BAK) ...
International audienceIntroduction: Ocular surface diseases with limbal insufficiency represent a th...
Objective To investigate the short-term impact on human conjunctival goblet cell (GC) survival and m...
International audienceDry eye disease (DED) is a multifactorial chronic inflammatory disease of the ...
PURPOSE: The aim of this study is to investigate the short-term effects of benzalkonium chloride (BA...
International audienceBenzalkonium chloride (BAK), a quaternary ammonium compound widely used as dis...
Benzalkonium chloride (BAK) is a cationic detergent with a very slow turnover. Because of its strong...
La sécheresse oculaire est une maladie multifactorielle invalidante affectant la qualité de vie des ...
International audiencePurpose: Benzalkonium chloride (BAK), the most commonly used preservative in e...
Models of benzalkonium chloride (BAC)-induced ocular disruption have been created and are widely use...
Purpose: To evaluate acute corneal epithelial toxicity induced by benzalkonium chloride (BAC) homolo...
Benzalkonium chloride (BAC) is the most common preservative in ophthalmic preparations. Here, we inv...
Aims: To study the long term toxic effects of intraocular benzalkonium chloride (BAC). Methods: 19 p...
Preservatives are a major component of the ophthalmic preparations in multi-dose bottles. The purpos...
The corneal epithelium is renewed by limbal stem cells (LSCs). Absence, damage or loss of the LSC po...
It is widely accepted today that stem cells in the adult corneal epithelium is located to the limbus...
International audienceIntroduction: Ocular surface diseases with limbal insufficiency represent a th...
Objective To investigate the short-term impact on human conjunctival goblet cell (GC) survival and m...
International audienceDry eye disease (DED) is a multifactorial chronic inflammatory disease of the ...
PURPOSE: The aim of this study is to investigate the short-term effects of benzalkonium chloride (BA...
International audienceBenzalkonium chloride (BAK), a quaternary ammonium compound widely used as dis...
Benzalkonium chloride (BAK) is a cationic detergent with a very slow turnover. Because of its strong...
La sécheresse oculaire est une maladie multifactorielle invalidante affectant la qualité de vie des ...
International audiencePurpose: Benzalkonium chloride (BAK), the most commonly used preservative in e...
Models of benzalkonium chloride (BAC)-induced ocular disruption have been created and are widely use...
Purpose: To evaluate acute corneal epithelial toxicity induced by benzalkonium chloride (BAC) homolo...
Benzalkonium chloride (BAC) is the most common preservative in ophthalmic preparations. Here, we inv...
Aims: To study the long term toxic effects of intraocular benzalkonium chloride (BAC). Methods: 19 p...
Preservatives are a major component of the ophthalmic preparations in multi-dose bottles. The purpos...
The corneal epithelium is renewed by limbal stem cells (LSCs). Absence, damage or loss of the LSC po...
It is widely accepted today that stem cells in the adult corneal epithelium is located to the limbus...
International audienceIntroduction: Ocular surface diseases with limbal insufficiency represent a th...
Objective To investigate the short-term impact on human conjunctival goblet cell (GC) survival and m...
International audienceDry eye disease (DED) is a multifactorial chronic inflammatory disease of the ...