Drug Research Methodology. Volume 3, the Detection and Quantitation of Drugs of Interest in Body Fluids from Drivers

NHTSA - Behavioral Safety Researchhttps://doi.org/10.21949/15255391980PDFResearch PaperJoscelyn, Kent B.Donelson, Alan C.University of Michigan. Highway Safety Research InstituteUnited States. National Highway Traffic Safety AdministrationUnited States. National Highway Traffic Safety AdministrationUnited StatesDrugged driversHighway safetyDrug useAccident risk forecastingExperimentsDrugsDrug testsDOT-HS-805-375UM-HSRI-80-18NTIS-PB80223530DOT-HS-7-01530Final reportThis report presents the findings of a workshop on the chemical analysis of human body fluids for drugs of interest in highway safety. A cross-disciplinary panel of experts reviewed the list of drugs of interest developed in a previous workshop and described an analytical perspective with which to address issues related to their detection and quantitation. Participants specified requirements in highway safety for the analysis of drugs and suggested approaches and techniques for determining their presence and amount in body fluids. Also summarized in this report are discussions of issues in the design of highway safety research involving drug analysis: the collection, handling, and storage of body fluid specimens; monitoring the quality of analytical results (proficiency testing of laboratories and quality control procedures); interpretation of analytical results, including collateral data needed for interpretation of findings; and the design of surveys of drug use among drivers. Recommendations developed by the panel are presented. An appendix that provides background information on the detection and quantitation of drugs in body fluids is included in the report. /Abstract from report summary page/129