International audienceIn this commentary of Koonin's target paper, we defend an extended view of CRISPR-Cas immunity by arguing that CRISPR-Cas includes, but cannot be reduced to, defence against nonself. CRISPR-Cas systems can target endogenous elements (for example in DNA repair) and tolerate exogenous elements (for example some phages). We conclude that the vocabulary of "defence" and "nonself" might be misleading when describing CRISPR-Cas systems.
All organisms need to continuously adapt to changes in their environment. Through horizontal gene tr...
The CRISPR/Cas system in prokaryotes provides resistance against invading viruses and plasmids. Thre...
The CRISPR/Cas system in prokaryotes provides resistance against invading viruses and plasmids. Thre...
In this commentary of Koonin’s target paper, we defend an extended view of CRISPR-Cas immunity by ar...
In his insightful review, Eugene V. Koonin discusses various aspects of CRISPR-Cas systems with a st...
Seminal studies showed that CRISPR-Cas systems provide adaptive immunity in prokaryotes and promisin...
Viruses are a common threat to cellular life, not the least to bacteria and archaea who constitute t...
CRISPR-Cas immune systems in bacteria and archaea record prior infections as spacers within each sys...
The recently discovered CRISPR (clustered regularly interspaced short palindromic repeat) defense sy...
All immune systems must distinguish self from non-self to repel invaders without inducing autoimmuni...
AbstractViruses are a common threat to cellular life, not the least to bacteria and archaea who cons...
Prokaryotes have evolved several defence mechanisms to protect themselves from viral predators. Clus...
We show that phage lysogenization, lysogens, and prophage induction are all targeted by CRISPR. The ...
The recently discovered CRISPR (clustered regularly interspaced short palindromic repeat) defense sy...
CRISPR-Cas systems are immune systems that protect bacteria and archaea against their viruses, bacte...
All organisms need to continuously adapt to changes in their environment. Through horizontal gene tr...
The CRISPR/Cas system in prokaryotes provides resistance against invading viruses and plasmids. Thre...
The CRISPR/Cas system in prokaryotes provides resistance against invading viruses and plasmids. Thre...
In this commentary of Koonin’s target paper, we defend an extended view of CRISPR-Cas immunity by ar...
In his insightful review, Eugene V. Koonin discusses various aspects of CRISPR-Cas systems with a st...
Seminal studies showed that CRISPR-Cas systems provide adaptive immunity in prokaryotes and promisin...
Viruses are a common threat to cellular life, not the least to bacteria and archaea who constitute t...
CRISPR-Cas immune systems in bacteria and archaea record prior infections as spacers within each sys...
The recently discovered CRISPR (clustered regularly interspaced short palindromic repeat) defense sy...
All immune systems must distinguish self from non-self to repel invaders without inducing autoimmuni...
AbstractViruses are a common threat to cellular life, not the least to bacteria and archaea who cons...
Prokaryotes have evolved several defence mechanisms to protect themselves from viral predators. Clus...
We show that phage lysogenization, lysogens, and prophage induction are all targeted by CRISPR. The ...
The recently discovered CRISPR (clustered regularly interspaced short palindromic repeat) defense sy...
CRISPR-Cas systems are immune systems that protect bacteria and archaea against their viruses, bacte...
All organisms need to continuously adapt to changes in their environment. Through horizontal gene tr...
The CRISPR/Cas system in prokaryotes provides resistance against invading viruses and plasmids. Thre...
The CRISPR/Cas system in prokaryotes provides resistance against invading viruses and plasmids. Thre...
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