NF‐κB transcription factor is required for inhibitory avoidance long‐term memory in mice
- Freudenthal, Ramiro A. M.
- Boccia, Mariano Martín
- Acosta, Gabriela Beatriz
- Blake, Mariano Guillermo
- Merlo, Emiliano
- Baratti, Carlos Maria
- Romano, Arturo Gabriel
DOIAbstract
Although it is generally accepted that memory consolidation requires regulation of gene expression, only a few transcription factors (TFs) have been clearly demonstrated to be specifically involved in this process. Increasing research data point to the participation of the Rel/nuclear factor‐κB (NF‐κB) family of TFs in memory and neural plasticity. Here we found that two independent inhibitors of NF‐κB induced memory impairment in the one‐trial step‐through inhibitory avoidance paradigm in mice: post‐training administration of the drug sulfasalazine and 2 h pretraining administration of a double‐stranded DNA oligonucleotide containing the NF‐κB consensus sequence (κB decoy). Conversely, one base mutation of the κB decoy (mut‐κB decoy) injec...
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