Antiplatelet Activity of Natural Bioactive Extracts from Mango (Mangifera Indica L.) and its By-Products

The potential antiplatelet aggregation effects of mango pulp and its by-products (peel, husk seed, and seed) due to the presence of bioactive compounds were explored. Among them, mango seed exhibited a 72% percentage inhibition of platelet aggregation induced by adenosine 5’-diphosphate (ADP) agonist with a demonstrated dose-dependent effect. This biological feature could be caused by the chemical differences in phenolic composition. Mango seed was especially rich in monogalloyl compounds, tetra- and penta-galloylglucose, ellagic acid, mangiferin, and benzophenones such as maclurin derivatives and iriflophenone glucoside. Mangiferin showed an inhibitory effect of 31%, suggesting its key role as one of the main contributors to the antiplatelet activity of mango seed. Therefore, mango seed could be postulated as a natural source of bioactive compounds with antiplatelet properties to design functional foods or complementary therapeutic treatments.Ibero-American Program of Science and Technology for Development, Red iberoamericana de aprovechamiento integral de alimentos autóctonos subutilizados (ALSUB-CYTED, 118RT0543). Financial support of projects from program of aid for R + D + i of the Andalusian plan for research, development and innovation (PAIDI 2020) of Junta de Andalucía and Junta de Comunidades de Castilla-La Mancha (SBPLY/17/180501/000509)