Genome regulation is essential for normal human health and development. Each cell in the body has the same copy of the entire genome but must express different genes at different times and to different levels. Control of gene transcription is a major mechanism of genome regulation, and one form of transcriptional control is mediated by long noncoding RNAs (lncRNAs), RNAs longer than 200 nucleotides which do not code for proteins. A key example of this is the function of the X-inactive specific transcript (Xist) in X chromosome inactivation in female eutherian mammals. Xist requires Repeat-A, a protein-binding module in its first two kilobases (2kb), to repress transcription. We report that when expressed as a standalone transcript in m...
Background: The establishment of facultative heterochromatin by X-chromosome inacti...
Repression of Xist RNA expression is considered a prerequisite to reversing X-chromosome inactivatio...
Dosage compensation in female placental animals is accomplished by silencing one of the two X-chromo...
Xist initiates XCI by spreading across the future inactive X-chromosome, excluding RNA polymerase II...
XIST RNA established the precedent for a noncoding RNA that stably associates with and regulates chr...
Mammalian genomes encode thousands of long non-coding (lnc) RNAs, many with important functions incl...
These studies address whether XIST RNA is properly localized to the X chromosome in somatic cells wh...
X chromosome inactivation (XCI) ensures an equal gene dosage between the sexes in placental mammals....
The inactive X chromosome’s (Xi) physical territory is microscopically devoid of transcriptional hal...
Despite decades of biochemical, proteomic and genetic characterizations of the Xist longnon-coding R...
X-chromosome inactivation ensures equal expression of mammalian male and female X-linked genes by tr...
Cis-repressive long non-coding RNAs (lncRNAs) spread Polycomb Repressive Complexes (PRCs) with...
X chromosome inactivation (XCI) is a process by which one X chromosome in female mammals is silenced...
X-chromosome inactivation is a mechanism that has evolved in mammalian females allowing dosage comp...
© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.The X...
Background: The establishment of facultative heterochromatin by X-chromosome inacti...
Repression of Xist RNA expression is considered a prerequisite to reversing X-chromosome inactivatio...
Dosage compensation in female placental animals is accomplished by silencing one of the two X-chromo...
Xist initiates XCI by spreading across the future inactive X-chromosome, excluding RNA polymerase II...
XIST RNA established the precedent for a noncoding RNA that stably associates with and regulates chr...
Mammalian genomes encode thousands of long non-coding (lnc) RNAs, many with important functions incl...
These studies address whether XIST RNA is properly localized to the X chromosome in somatic cells wh...
X chromosome inactivation (XCI) ensures an equal gene dosage between the sexes in placental mammals....
The inactive X chromosome’s (Xi) physical territory is microscopically devoid of transcriptional hal...
Despite decades of biochemical, proteomic and genetic characterizations of the Xist longnon-coding R...
X-chromosome inactivation ensures equal expression of mammalian male and female X-linked genes by tr...
Cis-repressive long non-coding RNAs (lncRNAs) spread Polycomb Repressive Complexes (PRCs) with...
X chromosome inactivation (XCI) is a process by which one X chromosome in female mammals is silenced...
X-chromosome inactivation is a mechanism that has evolved in mammalian females allowing dosage comp...
© The Author(s) 2019. Published by Oxford University Press on behalf of Nucleic Acids Research.The X...
Background: The establishment of facultative heterochromatin by X-chromosome inacti...
Repression of Xist RNA expression is considered a prerequisite to reversing X-chromosome inactivatio...
Dosage compensation in female placental animals is accomplished by silencing one of the two X-chromo...