Synthesis and Characterization of New Heterocyclic Compounds Derived from 2-Aminopyrimidine

In this study Schiff basses(1) have been prepared by the reaction of 2-aminopyrimidine with benzaldehyde derivatives then Thiazolidene-4-none (2) , imidazolidine-4-ones (3) , and oxazepine-4,7-diones (4) have been prepared from Schiff bases (1) by reaction with 2-mercaptoacetic acid ,glycine and malic anhydride respectively .1-phenyl-3-pyrimidin-2-yl urea(5) and thiourea(6) have been prepared from reaction of 2-aminopyrimidine with naphthylisocyanate and phenylisothiocyanate respectively.1,3-oxazolidine -4-one (7) ,3-phenyl-2,3-dihydrothiazol-2-yl pyrimidine amines (8) have been prepared from the reaction of urea or thiourea derivatives (5,6) with ethylchloroacetate ,p-phenylphenacyl bromide respectively. 2-chloro N-(pyrimidin-2-yl)acetamide (10) have been prepared from reaction of 2-aminopyrimidine with α-chloroacetyl chloride .thenoxazole-2,5- diamines(11) Thiazole-2,5-diamine (12) have been prepared by the reaction of the reaction of (10) with urea and thiourea respectively. All prepared compounds are elucidated by some spectroscopic methods (FTIR, H NMR ,C13 NMR).The biological and enzymatic activity of some prepared compounds are evaluate