Establishing mechanisms affecting the individual response to ionising radiation
- Averbeck, Dietrich
- Candéias, Serge,
- Chandna, Sudhir
- Foray, Nicolas
- Friedl, Anna
- Haghdoost, Siamak
- Jeggo, Pénélope
- Lumniczky, Katalin
- Paris, François
- Quintens, Roel
- Sabatier, Laure
DOIAbstract
International audiencePurpose: Humans are increasingly exposed to ionising radiation (IR). Both low (<100 mGy) and high doses can cause stochastic effects, including cancer; whereas doses above 100 mGy are needed to promote tissue or cell damage. 10-15% of radiotherapy (RT) patients suffer adverse reactions, described as displaying radiosensitivity (RS). Sensitivity to IR's stochastic effects is termed radiosusceptibility (RSu). To optimise radiation protection we need to understand the range of individual variability and underlying mechanisms. We review the potential mechanisms contributing to RS/RSu focusing on RS following RT, the most tractable RS group.Conclusions: The IR-induced DNA damage response (DDR) has been well characterised. P...
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