Molecular-glue-mediated proximity-induced degradation now allows unprecedented therapeutic targeting of previously undruggable proteins. Structures showing how aryl-sulfonamides mediate recruitment of the splicing factor RBM39 to the E3 CRL4(DCAF15) broaden the mechanistic principles by which molecular glues target ubiquitylation
Molecular glue degraders (MGDs) are small molecules that degrade proteins of interest via the ubiqui...
Targeting protein–protein interactions (PPIs) has become a common approach to tackle various disease...
Molecular glues represent an evolution in drug discovery, however, targeted stabilization of protein...
Molecular glue degraders are small, drug-like compounds that induce interactions between an E3 ubiqu...
Protein-protein interactions (PPIs) govern all biological processes. Some small molecules modulate P...
Targeted protein degradation with molecular glue degraders has arisen as a powerful therapeutic moda...
Molecular glue degraders are small, drug-like compounds that induce interactions between an E3 ubiqu...
Molecular glue (MG) compounds are a type of unique small molecule that can change the protein–protei...
Molecular Glues, here defined as small molecules that interact with two protein surfaces to induce o...
Molecular glues stabilize interactions between E3 ligases and novel substrates to promote substrate ...
Molecular glue compounds induce protein–protein interactions that, in the context of a ubiquitin l...
The stabilisation of protein-protein interactions (PPIs) through molecular glues is a novel and prom...
Molecular glues can specifically induce aggregation between two or more proteins to modulate biologi...
Molecular glue compounds induce protein–protein interactions that, in the context of a ubiquitin lig...
Targeted protein degradation has arisen as a powerful therapeutic modality for degrading disease tar...
Molecular glue degraders (MGDs) are small molecules that degrade proteins of interest via the ubiqui...
Targeting protein–protein interactions (PPIs) has become a common approach to tackle various disease...
Molecular glues represent an evolution in drug discovery, however, targeted stabilization of protein...
Molecular glue degraders are small, drug-like compounds that induce interactions between an E3 ubiqu...
Protein-protein interactions (PPIs) govern all biological processes. Some small molecules modulate P...
Targeted protein degradation with molecular glue degraders has arisen as a powerful therapeutic moda...
Molecular glue degraders are small, drug-like compounds that induce interactions between an E3 ubiqu...
Molecular glue (MG) compounds are a type of unique small molecule that can change the protein–protei...
Molecular Glues, here defined as small molecules that interact with two protein surfaces to induce o...
Molecular glues stabilize interactions between E3 ligases and novel substrates to promote substrate ...
Molecular glue compounds induce protein–protein interactions that, in the context of a ubiquitin l...
The stabilisation of protein-protein interactions (PPIs) through molecular glues is a novel and prom...
Molecular glues can specifically induce aggregation between two or more proteins to modulate biologi...
Molecular glue compounds induce protein–protein interactions that, in the context of a ubiquitin lig...
Targeted protein degradation has arisen as a powerful therapeutic modality for degrading disease tar...
Molecular glue degraders (MGDs) are small molecules that degrade proteins of interest via the ubiqui...
Targeting protein–protein interactions (PPIs) has become a common approach to tackle various disease...
Molecular glues represent an evolution in drug discovery, however, targeted stabilization of protein...
DOI
Add to ORKG