Amyotrophic lateral sclerosis (ALS) is a fatal adult-onset disease characterized by upper and lower motor neuron degeneration, muscle wasting and paralysis. Growing evidence suggests a link between changes in lipid metabolism and ALS. Here, we used UPLC/TOF-MS to survey the lipidome in SOD1(G86R) mice, a model of ALS. Significant changes in lipid expression were evident in spinal cord and skeletal muscle before overt neuropathology. In silico analysis also revealed appreciable changes in sphingolipids including ceramides and glucosylceramides (GlcCer). HPLC analysis showed increased amounts of GlcCer and downstream glycosphingolipids (GSLs) in SOD1(G86R) muscle compared with wild-type littermates. Glucosylceramide synthase (GCS), the enzyme...
Amyotrophic lateral sclerosis (ALS), the commonest adult-onset motor neuron disorder, is characteriz...
ALS patients and mouse model manifest metabolic dysfunctions that coincide with the modified levels ...
La sclérose latérale amyotrophique (SLA) est une maladie dégénérative neuromusculaire fatale. Elle e...
International audienceLipid metabolism is drastically dysregulated in amyotrophic lateral sclerosis ...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progre...
Recent metabolomic reports connect dysregulation of glycosphingolipids, particularly ceramide and gl...
International audienceRecent metabolomic reports connect dysregulation of glycosphingolipids, partic...
International audienceAmyotrophic lateral sclerosis (ALS) is the most common fatal motor neuron dise...
Recent metabolomic reports connect dysregulation of glycosphingolipids, particularly ceramide and gl...
International audienceAmyotrophic lateral sclerosis (ALS) is the most common adult motor neuron dise...
Historically, the early-onset rare neurodegenerative lysosomal storage disorders (LSDs) have been st...
Amyotrophic lateral sclerosis (ALS) is a fatal degenerative disease characterized by loss of upper a...
Amyotrophic lateral sclerosis is a neurodegenerative disease, associated with metabolic dysfunction....
International audienceSphingolipids are complex lipids. They play a structural role in neurons, but ...
Amyotrophic lateral sclerosis (ALS), the commonest adult-onset motor neuron disorder, is characteriz...
ALS patients and mouse model manifest metabolic dysfunctions that coincide with the modified levels ...
La sclérose latérale amyotrophique (SLA) est une maladie dégénérative neuromusculaire fatale. Elle e...
International audienceLipid metabolism is drastically dysregulated in amyotrophic lateral sclerosis ...
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progre...
Recent metabolomic reports connect dysregulation of glycosphingolipids, particularly ceramide and gl...
International audienceRecent metabolomic reports connect dysregulation of glycosphingolipids, partic...
International audienceAmyotrophic lateral sclerosis (ALS) is the most common fatal motor neuron dise...
Recent metabolomic reports connect dysregulation of glycosphingolipids, particularly ceramide and gl...
International audienceAmyotrophic lateral sclerosis (ALS) is the most common adult motor neuron dise...
Historically, the early-onset rare neurodegenerative lysosomal storage disorders (LSDs) have been st...
Amyotrophic lateral sclerosis (ALS) is a fatal degenerative disease characterized by loss of upper a...
Amyotrophic lateral sclerosis is a neurodegenerative disease, associated with metabolic dysfunction....
International audienceSphingolipids are complex lipids. They play a structural role in neurons, but ...
Amyotrophic lateral sclerosis (ALS), the commonest adult-onset motor neuron disorder, is characteriz...
ALS patients and mouse model manifest metabolic dysfunctions that coincide with the modified levels ...
La sclérose latérale amyotrophique (SLA) est une maladie dégénérative neuromusculaire fatale. Elle e...