This study aims at investigating the causes of damage and collapse of several residential masonry structures during the devastating seismic sequence that hit Central Italy in 2016. After analyzing the structural features of affected buildings, an extensive series of numerical analyses is performed for a sample two-story masonry building to better understand its seismic vulnerability and suggest valuable hints for the reconstruction of historical city centers. Each analysis is carried out by adopting realistic hypotheses concerning material properties, connection among multi-leaf walls, different roofing systems (e.g., use of RC slabs at the top of the buildings), and the presence of rigid or flexible floors. Numerical analyses consist of mo...