Stem-cell-derived human microglia transplanted in mouse brain to study human disease
- Mancuso, Renzo
- Van den Daele, Johanna
- Fattorelli, Nicola
- Wolfs, Leen
- Balusu, Sriram
- Burton, Oliver
- Liston, Adrian
- Sierksma, Annerieke
- Fourne, Yannick
- Poovathingal, Suresh
- Arranz-Mendiguren, Amaia
- Frigerio, Carlo Sala
- Claes, Christel
- Serneels, Lutgarde
- Theys, Tom
- Perry, V Hugh
- Verfaillie, Catherine
- Fiers, Mark
- De Strooper, Bart
Publication date
December 2019
DOI Publisher
Springer Science and Business Media LLC Journal
Nature NeuroscienceAbstract
Although genetics highlights the role of microglia in Alzheimer's disease, one-third of putative Alzheimer's disease risk genes lack adequate mouse orthologs. Here we successfully engraft human microglia derived from embryonic stem cells in the mouse brain. The cells recapitulate transcriptionally human primary microglia ex vivo and show expression of human-specific Alzheimer's disease risk genes. Oligomeric amyloid-β induces a divergent response in human versus mouse microglia. This model can be used to study the role of microglia in neurological diseases.status: publishe
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