Integrins are fundamental to the control of protrusion and motility in adherent cells. However, the mechanisms by which specific members of this receptor family cooperate in signaling to cytoskeletal and adhesion dynamics are poorly understood. Here, we show that the loss of ß3 integrin in fibroblasts results in enhanced focal adhesion turnover and migration speed but impaired directional motility on both 2D and 3D matrices. These motility defects are coupled with an increased rate of actin-based protrusion. Analysis of downstream signaling events reveals that loss of ß3 integrin results in a loss of protein kinase A–dependent phosphorylation of the actin regulatory protein vasodilator-stimulated phosphoprotein (VASP). Dephosphorylated VASP...
Cell adhesion and migration require a tightly regulated organization of cytoskeleton and cell-matrix...
The properties of epithelial cells within tissues are regulated by their immediate microenvironment,...
Cell-to-extracellular matrix adhesion is regulated by a multitude of pathways initiated distally to ...
Integrins are fundamental to the control of protrusion and motility in adherent cells. However, the ...
International audienceIntegrins in focal adhesions (FAs) mediate adhesion and force transmission to ...
International audienceCell migration is an integrated process requiring the continuous coordinated a...
The properties of epithelial cells within tissues are regulated by their immediate microenvironment,...
International audienceA cell constantly adapts to its environment. Cell decisions to survive, to pro...
Integrins are transmembrane receptors that, upon activation, bind extracellular ligands and link the...
Adhesive and migratory behavior can be cell type, integrin, and substrate dependent. We have compare...
cAMP is a pivotal second messenger that regulates a wide range of cellular processes. Besides protei...
During cell migration, the physical link between the extracellular substrate and the actin cytoskele...
Protein 4.1G is a membrane skeletal protein that can serve as an adapter between transmembrane prote...
The properties of epithelial cells within tissues are regulated by their immediate microenvironment,...
Integrin-mediated cell adhesions are highly regulated structures forming between the cell and the ex...
Cell adhesion and migration require a tightly regulated organization of cytoskeleton and cell-matrix...
The properties of epithelial cells within tissues are regulated by their immediate microenvironment,...
Cell-to-extracellular matrix adhesion is regulated by a multitude of pathways initiated distally to ...
Integrins are fundamental to the control of protrusion and motility in adherent cells. However, the ...
International audienceIntegrins in focal adhesions (FAs) mediate adhesion and force transmission to ...
International audienceCell migration is an integrated process requiring the continuous coordinated a...
The properties of epithelial cells within tissues are regulated by their immediate microenvironment,...
International audienceA cell constantly adapts to its environment. Cell decisions to survive, to pro...
Integrins are transmembrane receptors that, upon activation, bind extracellular ligands and link the...
Adhesive and migratory behavior can be cell type, integrin, and substrate dependent. We have compare...
cAMP is a pivotal second messenger that regulates a wide range of cellular processes. Besides protei...
During cell migration, the physical link between the extracellular substrate and the actin cytoskele...
Protein 4.1G is a membrane skeletal protein that can serve as an adapter between transmembrane prote...
The properties of epithelial cells within tissues are regulated by their immediate microenvironment,...
Integrin-mediated cell adhesions are highly regulated structures forming between the cell and the ex...
Cell adhesion and migration require a tightly regulated organization of cytoskeleton and cell-matrix...
The properties of epithelial cells within tissues are regulated by their immediate microenvironment,...
Cell-to-extracellular matrix adhesion is regulated by a multitude of pathways initiated distally to ...