Multiple endocrine neoplasia type 1 knockout mice develop parathyroid, pancreatic, pituitary and adrenal tumours with hypercalcaemia, hypophosphataemia and hypercorticosteronaemia.
- Harding, Brian
- Lemos, Manuel C.
- Reed, Anita A. C.
- Walls, Gerard V.
- Jeyabalan, Jeshmi
- Bowl, Michael R
- Tateossian, Hilda
- Sullivan, Nicky
- Hough, Tertius
- Fraser, William D.
- Ansorge, Olaf
- Cheeseman, Michael T.
- Thakker, Rajesh V.
Publication date
January 2009
DOIAbstract
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized in man by parathyroid, pancreatic, pituitary and adrenal tumours. The MEN1 gene encodes a 610-amino acid protein (menin) which is a tumour suppressor. To investigate the in vivo role of menin, we developed a mouse model, by deleting Men1 exons 1 and 2 and investigated this for MEN1-associated tumours and serum abnormalities. Men1(+/-) mice were viable and fertile, and 220 Men1(+/-) and 94 Men1(+/+) mice were studied between the ages of 3 and 21 months. Survival in Men1(+/-) mice was significantly lower than in Men1(+/+) mice
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