The effect of incorporating caffeine and paracetamol on the structure and behaviour of Gelucire 50/13 has been studied with a view to establishing whether the choice of drug influences the solid structure and release mechanism. Dispersions containing up to 30% w/w drug were prepared and studied using differential scanning calorimetry (DSC), hot stage differential interference contrast microscopy (HSM), dissolution studies and erosion, water uptake (WU) and diameter change measurements. Gelucire 50/13 alone showed a broad melting endotherm using DSC, with two dominant peaks at 36 and 44 °C. While incorporation of caffeine did not result in marked changes to the profile, the presence of paracetamol increased the proportion of material in the ...
The purpose of this investigation was to study the dissolution behavior of paracetamol and ibuprofen...
<p><i>Objective</i>: To study the solid state modifications of ibuprofen (IBU)-loaded spray-congeale...
The purpose of this study was to prepare and characterize solid dispersions of the antiviral thiocar...
The variety of components within Gelucires® can result in complex carrier characteristics ranging fr...
Gelucire 50/13 alone and solid dispersions in this material containing two model drugs (10% w/w caff...
In recent years there has been a growing interest in solid lipid-based systems, particularly in soli...
This study investigates the release mechanism of a hydrophilic drug (caffeine) from hydrophobic matr...
Solid dispersions have been employed as a method to improve the dissolution rate and hence the bioav...
The objective of this study was to compare the dissolution behavior of tablets prepared from solid d...
The production and physicochemical characterisation of spray chilled Gelucire 50/13 microspheres is ...
To improve its dissolution, ibuprofen solid dispersions (SDs) were prepared in a relatively easy and...
To improve its oral absorption, rapidly dissolving ibuprofen solid dispersions (SD) were prepared in...
The two main purposes of this work were: (i) to critically consider the use of thermodynamic paramet...
Freeze-dried systems (L) comprising chitosan (CS) and caffeine (CAF) have been developed for oral ad...
The present research work was carried out to develop sustained release tablets of caffeine using nat...
The purpose of this investigation was to study the dissolution behavior of paracetamol and ibuprofen...
<p><i>Objective</i>: To study the solid state modifications of ibuprofen (IBU)-loaded spray-congeale...
The purpose of this study was to prepare and characterize solid dispersions of the antiviral thiocar...
The variety of components within Gelucires® can result in complex carrier characteristics ranging fr...
Gelucire 50/13 alone and solid dispersions in this material containing two model drugs (10% w/w caff...
In recent years there has been a growing interest in solid lipid-based systems, particularly in soli...
This study investigates the release mechanism of a hydrophilic drug (caffeine) from hydrophobic matr...
Solid dispersions have been employed as a method to improve the dissolution rate and hence the bioav...
The objective of this study was to compare the dissolution behavior of tablets prepared from solid d...
The production and physicochemical characterisation of spray chilled Gelucire 50/13 microspheres is ...
To improve its dissolution, ibuprofen solid dispersions (SDs) were prepared in a relatively easy and...
To improve its oral absorption, rapidly dissolving ibuprofen solid dispersions (SD) were prepared in...
The two main purposes of this work were: (i) to critically consider the use of thermodynamic paramet...
Freeze-dried systems (L) comprising chitosan (CS) and caffeine (CAF) have been developed for oral ad...
The present research work was carried out to develop sustained release tablets of caffeine using nat...
The purpose of this investigation was to study the dissolution behavior of paracetamol and ibuprofen...
<p><i>Objective</i>: To study the solid state modifications of ibuprofen (IBU)-loaded spray-congeale...
The purpose of this study was to prepare and characterize solid dispersions of the antiviral thiocar...