MIKROALGA LAUT Nannochloropsis Oculata SEBAGAI ALTERNATIF ANTIVIRUS Viral Nervous Necrotic (VNN) PADAIKAN KERAPU TIKUS (Cromileptes Altivelis)

Viral nervous necrosis (VNN) is the causative agent of the disease that quite dangerous for the survival of grouper farming (C. altivelis). Impacts this virus attacks are capable of causing up to 100% mortality. For overcome attack VNN can be used materials of biological resources is N. oculata. Utilization marine microalgae N. oculata were able to improve the immune system, boost the immune response by improving the expression of Toll-like Receptor (TLR) expression Major Histocompitability Complex (MHC), were able to inducing antiviral genes (P56), and able to provide an anti-inflammatory effect. With these capabilities. Feasible to develop the utilization of marine microalgae N. oculata as an alternative to tackling VNN attack on C. altivelis.Viral nervous necrotic (VNN) merupakan agen penyebab penyakit yang cukup berbahaya bagi keberlangsungan budidaya ikan Kerapu Tikus (C. altivelis). Dampak serangan virus ini mampu menyebabkan mortalitas hingga 100%. Untuk menanggulangi serangan VNN dapat digunakan bahan sumberdaya hayati yaitu N. oculata .Pemanfaatan mikroalga laut N. oculatamampu meningkatkan sistem imun, meningkatkan respon imun dengan cara meningkatkan ekpresi Toll-like Receptor (TLR), ekpresi Major Histocompitability Complex (MHC),  mampu menginduksi gen antivirus (P56), dan mampu memberikan efek anti-inflamasi. Dengan berbagai kemampuan tersebut, layak untuk dikembangkan pemanfaatan mikroalga laut N. oculatasebagai alternatif untuk menanggulangi serangan VNN pada C. Altivelis