Add to ORKGJournal ArticleWe used a recently developed method to produce mutant alleles of five endogenous Drosophila genes, including the homolog of the p53 tumor suppressor. Transgenic expression of the FLP site-specific recombinase and the I-SceI endonuclease generates extrachromosomal linear DNA molecules in vivo
The generation and analysis of mutants is central to studies of gene function in model organisms. Me...
BACKGROUND: Gene targeting would offer a number of advantages over current transposon-based strategi...
SummaryHere, we present a simple and highly efficient method for generating and detecting mutations ...
Journal ArticleWe used a recently developed method to produce mutant alleles of five endogenous Dros...
We used a recently developed method to produce mutant alleles of five endogenous Drosophila genes, i...
Journal ArticleThe technology of modifying endogenous genes has recently been extended from mice to ...
Date received (in revised form): 9th May 2003 By utilising a cell’s recombinational machinery, resea...
Modifying the genomes of many organisms is becoming as easy as manipulating DNA in test tubes, which...
BACKGROUND: Recent progress in insect transgenesis has been dramatic but existing transposon-based a...
AbstractRecent advances in our ability to design DNA binding factors with specificity for desired se...
The generation and analysis of mutants is central to studies of gene function in model organisms. Me...
Modern molecular genetics studies necessitate the manipulation of genes in their endogenous locus, b...
A central goal in the development of genome engineering technology is to reduce the time and labor r...
Adoption of a streamlined version of the bacterial clustered regular interspersed short palindromic ...
A central challenge in investigating biological phenomena is the development of techniques to modify...
The generation and analysis of mutants is central to studies of gene function in model organisms. Me...
BACKGROUND: Gene targeting would offer a number of advantages over current transposon-based strategi...
SummaryHere, we present a simple and highly efficient method for generating and detecting mutations ...
Journal ArticleWe used a recently developed method to produce mutant alleles of five endogenous Dros...
We used a recently developed method to produce mutant alleles of five endogenous Drosophila genes, i...
Journal ArticleThe technology of modifying endogenous genes has recently been extended from mice to ...
Date received (in revised form): 9th May 2003 By utilising a cell’s recombinational machinery, resea...
Modifying the genomes of many organisms is becoming as easy as manipulating DNA in test tubes, which...
BACKGROUND: Recent progress in insect transgenesis has been dramatic but existing transposon-based a...
AbstractRecent advances in our ability to design DNA binding factors with specificity for desired se...
The generation and analysis of mutants is central to studies of gene function in model organisms. Me...
Modern molecular genetics studies necessitate the manipulation of genes in their endogenous locus, b...
A central goal in the development of genome engineering technology is to reduce the time and labor r...
Adoption of a streamlined version of the bacterial clustered regular interspersed short palindromic ...
A central challenge in investigating biological phenomena is the development of techniques to modify...
The generation and analysis of mutants is central to studies of gene function in model organisms. Me...
BACKGROUND: Gene targeting would offer a number of advantages over current transposon-based strategi...
SummaryHere, we present a simple and highly efficient method for generating and detecting mutations ...