Add to ORKGdissertationPactamycin was isolated in 1961 by the former UpJohn Company and to date is the most complex aminocyclopentinol known. This natural metabolite is decorated by six contiguous stereocenters, three of which are quaternary, with each position of the cyclopen
The widespread failure of antibiotics in the treatment of multidrug-resistant (MDR) or biofilm-assoc...
Several unique strategies were developed and employed in the synthesis of 2-(1,2-dihydroxy-1-oxirany...
Inspired by their naturally occurring members, the carbapenem class of β-lactam antibiotics have bee...
Among the myriad of naturally occurring bioactive compounds are the aminocyclopentitol-containing na...
Platensimycin/platencin are recently discovered natural products that inhibit membrane formation in ...
Graduation date: 2015Access restricted to the OSU Community, at author's request, from June 25, 2015...
Microbial natural products are an important source of novel medicines in an ongoing war against drug...
The research discussed in this dissertation focuses on the synthesis and biological evaluation of tw...
Antibiotics are a cornerstone of modern medicine and have drastically reduced the burden of infectio...
The research described in this dissertation is at the interface of organic chemistry and biology, an...
Pathogenic microorganisms often have the ability to attach to a surface, building a complex matrix w...
University of Minnesota Ph.D. dissertation. May 2020. Major: Medicinal Chemistry. Advisor: Courtney ...
Three model hydantoin-based universal peptidomimetics are designed and synthetized. Their preferred...
Chemical communication mediates the vast majority of collective bacterial behaviors, orchestrating g...
This dissertation is focused on exploring the potential of bacteria for the biosynthesis of natural ...
The widespread failure of antibiotics in the treatment of multidrug-resistant (MDR) or biofilm-assoc...
Several unique strategies were developed and employed in the synthesis of 2-(1,2-dihydroxy-1-oxirany...
Inspired by their naturally occurring members, the carbapenem class of β-lactam antibiotics have bee...
Among the myriad of naturally occurring bioactive compounds are the aminocyclopentitol-containing na...
Platensimycin/platencin are recently discovered natural products that inhibit membrane formation in ...
Graduation date: 2015Access restricted to the OSU Community, at author's request, from June 25, 2015...
Microbial natural products are an important source of novel medicines in an ongoing war against drug...
The research discussed in this dissertation focuses on the synthesis and biological evaluation of tw...
Antibiotics are a cornerstone of modern medicine and have drastically reduced the burden of infectio...
The research described in this dissertation is at the interface of organic chemistry and biology, an...
Pathogenic microorganisms often have the ability to attach to a surface, building a complex matrix w...
University of Minnesota Ph.D. dissertation. May 2020. Major: Medicinal Chemistry. Advisor: Courtney ...
Three model hydantoin-based universal peptidomimetics are designed and synthetized. Their preferred...
Chemical communication mediates the vast majority of collective bacterial behaviors, orchestrating g...
This dissertation is focused on exploring the potential of bacteria for the biosynthesis of natural ...
The widespread failure of antibiotics in the treatment of multidrug-resistant (MDR) or biofilm-assoc...
Several unique strategies were developed and employed in the synthesis of 2-(1,2-dihydroxy-1-oxirany...
Inspired by their naturally occurring members, the carbapenem class of β-lactam antibiotics have bee...