Add to ORKGScientists today are learning exactly how disease-causing genes trip up the body's healthy functioning, thanks to a feat of molecular wizardry that is becoming as essential to researchers worldwide as a hammer is to a carpenter. Known as gene targeting, this revolutionary technique enables scientists to engineer mice with any gene defect imaginable, to create accurate models of cancer, high blood pressure, arteriosclerosis and a host of other diseases
Over the past decade the availability of new investigational tools including genetically modified mo...
Gene targeting allows precise, predetermined changes to be made in a chosen gene in the mouse genome...
Because of shared physiological, anatomical and metabolical features with humans, mice have served f...
Two major innovations in the 1980s have changed all fields of biomedicine. Combination of gene targe...
The 2007 Nobel Prize in Physiology or Medicine has been awarded to Mario Capecchi, Martin Evans, and...
As this century draws to a close, spectacular advances in the fields of genomics and genetics are op...
One of today's most powerful technologies in biomedical research—the creation of mutant mice by gene...
The ability to target DNA specifically at any given position within the genome allows many intriguin...
There have been many changes in the science of drug discovery in the past decade. One advance that s...
Mutations in whole organisms are powerful ways of interrogating gene function in a realistic context...
Mutations in whole organisms are powerful ways of interrogating gene function in a realistic context...
SummaryMutations in whole organisms are powerful ways of interrogating gene function in a realistic ...
The Nobel Prize in Physiology or Medicine was awarded this year to Andrew Fire (Stanford Universit...
Analyses of the human genome have proven extremely successful in identifying changes that contribute...
Click on the link below to access the article (may not be free).A valuable approach to investigating...
Over the past decade the availability of new investigational tools including genetically modified mo...
Gene targeting allows precise, predetermined changes to be made in a chosen gene in the mouse genome...
Because of shared physiological, anatomical and metabolical features with humans, mice have served f...
Two major innovations in the 1980s have changed all fields of biomedicine. Combination of gene targe...
The 2007 Nobel Prize in Physiology or Medicine has been awarded to Mario Capecchi, Martin Evans, and...
As this century draws to a close, spectacular advances in the fields of genomics and genetics are op...
One of today's most powerful technologies in biomedical research—the creation of mutant mice by gene...
The ability to target DNA specifically at any given position within the genome allows many intriguin...
There have been many changes in the science of drug discovery in the past decade. One advance that s...
Mutations in whole organisms are powerful ways of interrogating gene function in a realistic context...
Mutations in whole organisms are powerful ways of interrogating gene function in a realistic context...
SummaryMutations in whole organisms are powerful ways of interrogating gene function in a realistic ...
The Nobel Prize in Physiology or Medicine was awarded this year to Andrew Fire (Stanford Universit...
Analyses of the human genome have proven extremely successful in identifying changes that contribute...
Click on the link below to access the article (may not be free).A valuable approach to investigating...
Over the past decade the availability of new investigational tools including genetically modified mo...
Gene targeting allows precise, predetermined changes to be made in a chosen gene in the mouse genome...
Because of shared physiological, anatomical and metabolical features with humans, mice have served f...