The characteristic lesion in patients with myelinoclastic diffuse sclerosis is a large, sharply outlined, asymmetric focus of demyelination with severe, selective myelinoclasia that often affects an entire lobe or cerebral hemisphere. There is typically extension across the corpus callosum and damage to the opposite hemisphere. Both hemispheres are symmetrically affected in some cases. Careful examination of the optic nerves, brainstem, cerebellum, and spinal cord often discloses typical discrete lesions consistent with MS, and histopathologic examination of both large and small foci reveals the characteristic features reminiscent of MS, including fibrillary gliosis with formation of giant multinucleated or swollen astrocytes and perivascul...
OBJECTIVE: To investigate distinct white matter and cortical gray matter pathology in neuromyelitis ...
Background: Spinal cord (SC) lesions in Theiler’s murine encephalomyelitis virus induced demyelinati...
<p>Huge, active demyelinating lesions with perivascular lymphocytic cuffing (A) and infiltrating foa...
Both the clinical and histopathologic features of myelinoclastic diffuse sclerosis suggest that it i...
The gross pathology in patients with chronic MS is typical. In the majority of cases, the brain show...
In 1912, Schilder reported the case of a 12-year-old girl who experienced rapidly progressive mental...
Although multiple sclerosis (MS) has been considered a white matter disease, MS lesions are known to...
The histopathology of multiple sclerosis (MS), the most common demyelinating disorder, is the main f...
Abstract Multiple sclerosis (MS) is typically considered to be a chronic inflammatory-demyelinating ...
The diagnosis of myelinoclastic diffuse sclerosis should be suspected when a child or young adult de...
In 1912, Schilder reportedthe case of a 12-year-oldgirl who experienced rapidly progressive mental d...
Myelinoclastic diffuse sclerosis occurs most often in children and young adults, but may occasionall...
Aim: Multiple sclerosis (MS) is an inflammatory demyelinating and neurodegenerative disease. Much of...
Abstract Although historically considered a disease primarily affecting the white matter of the cent...
The key pathological feature of multiple sclerosis (MS) is the focal white matter lesion, harboring ...
OBJECTIVE: To investigate distinct white matter and cortical gray matter pathology in neuromyelitis ...
Background: Spinal cord (SC) lesions in Theiler’s murine encephalomyelitis virus induced demyelinati...
<p>Huge, active demyelinating lesions with perivascular lymphocytic cuffing (A) and infiltrating foa...
Both the clinical and histopathologic features of myelinoclastic diffuse sclerosis suggest that it i...
The gross pathology in patients with chronic MS is typical. In the majority of cases, the brain show...
In 1912, Schilder reported the case of a 12-year-old girl who experienced rapidly progressive mental...
Although multiple sclerosis (MS) has been considered a white matter disease, MS lesions are known to...
The histopathology of multiple sclerosis (MS), the most common demyelinating disorder, is the main f...
Abstract Multiple sclerosis (MS) is typically considered to be a chronic inflammatory-demyelinating ...
The diagnosis of myelinoclastic diffuse sclerosis should be suspected when a child or young adult de...
In 1912, Schilder reportedthe case of a 12-year-oldgirl who experienced rapidly progressive mental d...
Myelinoclastic diffuse sclerosis occurs most often in children and young adults, but may occasionall...
Aim: Multiple sclerosis (MS) is an inflammatory demyelinating and neurodegenerative disease. Much of...
Abstract Although historically considered a disease primarily affecting the white matter of the cent...
The key pathological feature of multiple sclerosis (MS) is the focal white matter lesion, harboring ...
OBJECTIVE: To investigate distinct white matter and cortical gray matter pathology in neuromyelitis ...
Background: Spinal cord (SC) lesions in Theiler’s murine encephalomyelitis virus induced demyelinati...
<p>Huge, active demyelinating lesions with perivascular lymphocytic cuffing (A) and infiltrating foa...