Add to ORKGMost chemotherapeutic medications act on rapidly dividing tumor cells. Because the majority of cells in the brain and spinal cord, including neurons and astrocytes, undergo little cellular division, acute effects of many chemotherapeutic agents are less prominent in the central nervous system (CNS) than in other organs. Another factor protecting the CNS from toxicity is the blood-brain barrier (BBB), which limits the amount of ionized and water-soluble drug that can reach the brain. Nonetheless, neurologic toxicity is frequently observed and is often the dose-limiting side effect of the treatment
Background: Brain tumor vasculature can be significantly compromised and leakier than that of normal...
Patients with cancer frequently have neurologic, ophthalmologic, or neuro-ophthalmologic complicatio...
Various neurological complications, affecting both the central and peripheral nervous system, can fr...
Historically, body tissues with a high rate of cell turnover, such as the bone marrow, have been mos...
Since the first clinical trials conducted after World War II, chemotherapeutic drugs have been exten...
Nearly 12.5 million new cancer cases are diagnosed worldwide each year. Although new treatments have...
International audienceIntroduction: Glioblastomas (GBM) are the most common and aggressive primary m...
Item does not contain fulltextNeurotoxic side effects of chemotherapy occur frequently and are often...
International audienceChemotherapy may have detrimental effects on either the central or peripheral ...
Chemotherapy has prolonged the survival rates of cancer patients. However, chemotherapy causes perip...
The increasing number of people who survive in the long term because of the advanced of glioma thera...
Oxaliplatin is a key drug in the treatment of advanced metastatic colorectal cancer. Despite its ben...
Title: “A comparative study of the impact of sustained and intermittent docetaxel chemotherapy in br...
Exposure to radiation during the treatment of CNS tumors leads to detrimental damage of the blood br...
Chemotherapy-induced neurotoxicity can reduce the quality of life of patients by affecting their int...
Background: Brain tumor vasculature can be significantly compromised and leakier than that of normal...
Patients with cancer frequently have neurologic, ophthalmologic, or neuro-ophthalmologic complicatio...
Various neurological complications, affecting both the central and peripheral nervous system, can fr...
Historically, body tissues with a high rate of cell turnover, such as the bone marrow, have been mos...
Since the first clinical trials conducted after World War II, chemotherapeutic drugs have been exten...
Nearly 12.5 million new cancer cases are diagnosed worldwide each year. Although new treatments have...
International audienceIntroduction: Glioblastomas (GBM) are the most common and aggressive primary m...
Item does not contain fulltextNeurotoxic side effects of chemotherapy occur frequently and are often...
International audienceChemotherapy may have detrimental effects on either the central or peripheral ...
Chemotherapy has prolonged the survival rates of cancer patients. However, chemotherapy causes perip...
The increasing number of people who survive in the long term because of the advanced of glioma thera...
Oxaliplatin is a key drug in the treatment of advanced metastatic colorectal cancer. Despite its ben...
Title: “A comparative study of the impact of sustained and intermittent docetaxel chemotherapy in br...
Exposure to radiation during the treatment of CNS tumors leads to detrimental damage of the blood br...
Chemotherapy-induced neurotoxicity can reduce the quality of life of patients by affecting their int...
Background: Brain tumor vasculature can be significantly compromised and leakier than that of normal...
Patients with cancer frequently have neurologic, ophthalmologic, or neuro-ophthalmologic complicatio...
Various neurological complications, affecting both the central and peripheral nervous system, can fr...