Bilateral optic atrophy with novel MTTL 3268 A>G homoplasmy - LHON variant or not?

Leber's Hereditary Optic Neuropathy is well known as a maternally inherited eye disease with symptoms of bilateral visual loss that affect generally young male, related predominantly with mitochondrial DNA mutations such as ND1 G3460A, ND4 G11778A and ND6 T14484C. With data accumulated and bio-molecular-genetic methods developed, several novel mutations were reported