: This is a 45-year-old woman with a chronic progressive cerebellopathy of unclear etiology (worsening over at least 10 years) characterized by gait and limb ataxia, gaze-evoked nystagmus, saccadic pursuit and vestibulo-ocular reflex suppression, an esotropia greater at distance, along with very mild downbeat nystagmus (DBN), mainly seen with the ophthalmoscope. This constellation of ocular motor signs localizes well to the flocculus/paraflocculus. Following 40 seconds of hyperventilation, which induces alkalosis and alters intra- and extracellular calcium concentrations, she demonstrated prominent DBN. This finding has been described in patients with cerebellar pathology, and has been theorized to relate to sensitivity of cerebellar volta...
: This is a 70-year-old man who experienced the gradual onset of oscillopsia over weeks about 3 mont...
: This is a 75-year-old woman with a diagnosis of progressive supranuclear palsy (PSP). Examination ...
: This is a 45-yo-man who was recently diagnosed with SCA 6. There was no clear spontaneous downbeat...
: Hyperventilation induced nystagmus is tested by asking the patient to take quick deep breaths (~1/...
: This is a 60-yo-woman with several years of worsening imbalance, diplopia (hers was actually unrel...
: This is a 45-yo-woman with vertical oscillopsia for 6+ months, found to have downbeat nystagmus on...
: This is a 40-year-old man with 2 years of progressive ataxia and oscillopsia. On examination, he h...
: This is a 30-year-old woman with a several year long history of imbalance due to cerebellar ataxia...
: 30-yo-man with the subacute onset of a cerebellar syndrome. After extensive evaluation and progres...
Hyperventilation: instruct the patient to breathe rapidly in and out of their mouth for 40-60 second...
: This is a 30-yo-man with a diagnosis of SCA 8 who had appendicular and gait ataxia in addition to ...
: This is a 70-year-old woman who presented with diplopia at distance. Her exam demonstrated orthoph...
: This is a 50-yo-woman with imbalance, and with fixation removed on her examination (with Frenzel g...
: This 50-yo-man complained of imbalance for several years and more recently oscillopsia. On examina...
: This patient complained of chronic (unexplained cough), progressive numbness in the legs and feet,...
: This is a 70-year-old man who experienced the gradual onset of oscillopsia over weeks about 3 mont...
: This is a 75-year-old woman with a diagnosis of progressive supranuclear palsy (PSP). Examination ...
: This is a 45-yo-man who was recently diagnosed with SCA 6. There was no clear spontaneous downbeat...
: Hyperventilation induced nystagmus is tested by asking the patient to take quick deep breaths (~1/...
: This is a 60-yo-woman with several years of worsening imbalance, diplopia (hers was actually unrel...
: This is a 45-yo-woman with vertical oscillopsia for 6+ months, found to have downbeat nystagmus on...
: This is a 40-year-old man with 2 years of progressive ataxia and oscillopsia. On examination, he h...
: This is a 30-year-old woman with a several year long history of imbalance due to cerebellar ataxia...
: 30-yo-man with the subacute onset of a cerebellar syndrome. After extensive evaluation and progres...
Hyperventilation: instruct the patient to breathe rapidly in and out of their mouth for 40-60 second...
: This is a 30-yo-man with a diagnosis of SCA 8 who had appendicular and gait ataxia in addition to ...
: This is a 70-year-old woman who presented with diplopia at distance. Her exam demonstrated orthoph...
: This is a 50-yo-woman with imbalance, and with fixation removed on her examination (with Frenzel g...
: This 50-yo-man complained of imbalance for several years and more recently oscillopsia. On examina...
: This patient complained of chronic (unexplained cough), progressive numbness in the legs and feet,...
: This is a 70-year-old man who experienced the gradual onset of oscillopsia over weeks about 3 mont...
: This is a 75-year-old woman with a diagnosis of progressive supranuclear palsy (PSP). Examination ...
: This is a 45-yo-man who was recently diagnosed with SCA 6. There was no clear spontaneous downbeat...