Add to ORKGThe cyclohexane-based conformationally controlled molecular switches provide a new and promising approach to allosteric systems with negative cooperativity. Protonation of trans-2- aminocyclohexanols leads to dramatic conformational changes: due to an intramolecular hydrogen bond, a conformer with equatorial position of ammonio- and hydroxy-groups becomes predominant. This ‘impulse’ is mechanically transmitted by the structure of the molecule, inducing a conformational change in the second site, thus altering its properties, e.g. decreasing its affinity to an appropriate guest, or changing a distance between groups of atoms. The variation of NR2 groups allows a broad tuning of the conformational equilibrium. These structures can serve as po...
Amino-cyclohexanol derivatives have been successful models for pH-triggered conformational switches....
Recently we described a novel strategy to render pH-sensitive lipid amphiphiles and their colloids: ...
Amino-cyclohexanol derivatives have been successful models for acid-triggered conformational switche...
The cyclohexane-based conformationally controlled molecular switches provide a new and promising app...
Properly designed trans-2-aminocyclohexanols possess a negative allosteric cooperativity and can ser...
Our group studies molecular switches that change their shape dramatically within a specific pH range...
Amino-cyclohexanol derivatives have been successful models for pH-triggered conformational switches....
We developed a novel strategy to render liposomes pH-sensitive: a protonation-induced conformational...
The conformationally controlled molecular switches provide a new and promising approach to substance...
Trans-2-Aminocyclohexanol (TACH) is a promising model for pH-triggerable molecular switches with a v...
Acid-sensitive liposome has drawn much interest as drug and gene carriers that release payloads spec...
Protonation-induced conformational change of lipid tails is reported as a novel strategy to render p...
In the past, aminocyclohexanol rings have been successfully utilized as pH-triggered molecular switc...
We suggested recently a novel approach to making lipid amphiphiles and their colloids pH-sensitive: ...
Amino-cyclohexanol derivatives have been successful models for pH-triggered conformational switches....
Recently we described a novel strategy to render pH-sensitive lipid amphiphiles and their colloids: ...
Amino-cyclohexanol derivatives have been successful models for acid-triggered conformational switche...
The cyclohexane-based conformationally controlled molecular switches provide a new and promising app...
Properly designed trans-2-aminocyclohexanols possess a negative allosteric cooperativity and can ser...
Our group studies molecular switches that change their shape dramatically within a specific pH range...
Amino-cyclohexanol derivatives have been successful models for pH-triggered conformational switches....
We developed a novel strategy to render liposomes pH-sensitive: a protonation-induced conformational...
The conformationally controlled molecular switches provide a new and promising approach to substance...
Trans-2-Aminocyclohexanol (TACH) is a promising model for pH-triggerable molecular switches with a v...
Acid-sensitive liposome has drawn much interest as drug and gene carriers that release payloads spec...
Protonation-induced conformational change of lipid tails is reported as a novel strategy to render p...
In the past, aminocyclohexanol rings have been successfully utilized as pH-triggered molecular switc...
We suggested recently a novel approach to making lipid amphiphiles and their colloids pH-sensitive: ...
Amino-cyclohexanol derivatives have been successful models for pH-triggered conformational switches....
Recently we described a novel strategy to render pH-sensitive lipid amphiphiles and their colloids: ...
Amino-cyclohexanol derivatives have been successful models for acid-triggered conformational switche...